Open Access

Association between neutrophil recruitment and lung inflammation in type I hypersensitivity reaction

  • Authors:
    • Raed Madhi
    • Anwar Algaber
    • Maha Chasib Munshid
    • Khadija Ibrahim Jassim
  • View Affiliations

  • Published online on: June 11, 2024     https://doi.org/10.3892/wasj.2024.253
  • Article Number: 38
  • Copyright : © Madhi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Type I hypersensitivity reactions can result in pulmonary inflammation via increasing the bronchospasm and mucous secretions in the airways of lungs; however, the participation of neutrophils in pulmonary inflammation mediated by type I hypersensitivity reactions are incompletely understood. The present study thus aimed to examine the association between neutrophil recruitment and lung inflammation in patients with type I hypersensitivity reactions. For this purpose, blood samples, that were obtained from 128 individuals with type I hypersensitivity reactions and 40 individuals who served as the controls, were analyzed to measure the levels of immunoglobulin E (IgE), basophils, neutrophils, platelet distribution width (PDW) and red blood cell distribution width (RDW). Moreover, sputum neutrophils were also measured in both the patients and the controls. In addition, consolidation areas were identified by specialist radiologist staff. The results revealed a significant increase in the levels of IgE and basophils corresponding to 91 and 79%, respectively, in patients with type I hypersensitivity reactions. The present study also observed a marked increase in the number of neutrophils in the blood and sputum of patients. Moreover, the results revealed that the levels of PDW and RDW were significantly increased in the patients. In addition, a marked association (y=1.3061x+0.3546) (R²=0.7067) between the infiltrated neutrophils and the consolidation area in the lungs. On the whole, the present study demonstrates a notable association between neutrophil recruitment and lung inflammation in patients with type 1 hypersensitivity reactions; thus, neutrophils may prove useful as a therapeutic target for protection against pulmonary inflammation. Moreover, the presence of neutrophils in sputum may also be used as a biomarker of pulmonary inflammation mediated by type I hypersensitivity reactions.

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July-August 2024
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Spandidos Publications style
Madhi R, Algaber A, Munshid MC and Jassim KI: Association between neutrophil recruitment and lung inflammation in type I hypersensitivity reaction. World Acad Sci J 6: 38, 2024
APA
Madhi, R., Algaber, A., Munshid, M.C., & Jassim, K.I. (2024). Association between neutrophil recruitment and lung inflammation in type I hypersensitivity reaction. World Academy of Sciences Journal, 6, 38. https://doi.org/10.3892/wasj.2024.253
MLA
Madhi, R., Algaber, A., Munshid, M. C., Jassim, K. I."Association between neutrophil recruitment and lung inflammation in type I hypersensitivity reaction". World Academy of Sciences Journal 6.4 (2024): 38.
Chicago
Madhi, R., Algaber, A., Munshid, M. C., Jassim, K. I."Association between neutrophil recruitment and lung inflammation in type I hypersensitivity reaction". World Academy of Sciences Journal 6, no. 4 (2024): 38. https://doi.org/10.3892/wasj.2024.253