World Academy of Sciences Journal Special Issues

Natural Products & Phytotherapeutics - Preclinical and Human Studies

Lead Editor:

    Dr Marcello Iriti
    Milan State University

Since ancient times, humanity has used medicinal plants to heal itself and traditional medicine still represents the predominant health care system in many parts of the world. Indeed, the use of natural products and their synthetic derivatives is central to the discovery of new drugs, especially antibacterial and anticancer agents. However, natural product research suffers from some important weaknesses. Despite hundreds of preclinical studies, evidence in human is scanty, due to the paucity of clinical trials evaluating the efficacy of natural products. Poor oral bioavailability is another major issue as phytochemicals are metabolized and eliminated by metabolizing enzymes and efflux mechanisms, similar to xenobiotics. Finally, natural does not always mean safe. The safety of natural products is rarely investigated as well as the phytochemical-drug interactions with possible variations in therapeutic efficacy for some drugs with a narrow therapeutic index. The combination of natural products with conventional drugs, particularly anticancer and antimicrobial drugs, represents another therapeutic approach able to (chemo)sensitize chemoresistant cancer cells and pathogens. The rationale for the use of natural products is based on their multitarget action mechanism of particular interest in the treatment of disorders with multistage pathogenesis. In this very wide context, we invite investigators to submit both original research and review articles that explore all these aspects.

Submission deadline: 06 January 2024

Exosomes and epigenetics in tumor growth and metastasisation

Lead Editor:

    Professor Ciro Isidoro
    Università del Piemonte Orientale "A. Avogadro"

Exosomes (and extracellular vesicles in general) released in the tumor microenvironment play a pivotal role in the cross-talk between cancer and stromal cells, influencing the growth and invasive behavior of the tumor cells and the phenoconversion of fibroblasts, adipocytes, and macrophages. Exosomes contain non-coding RNAs, cytokines, and metabolite intermediates that impinge on the metabolism as well as on the gene expression of the recipient cells. Of relevance for metastasisation is the epigenetic modulation of oncogenes and tumor suppressor genes regulating cell motility and Epithelial-to-Mesenchymal Transition (EMT). This Special Issue will collect review and research articles reporting on the biogenesis, content, release, and role of exosomes in the tumor microenvironment, with a focus on the induction of epigenetic changes associated with the malignant behavior of cancer cells.

Submission deadline: 01 June 2023

COVID-19 and autoimmunity

Lead Editor:

    Professor Dimitrios P. Bogdanos
    Division of Medicine, Faculty of Medicine, University of Thessaly

COVID-19, the disease caused by SARS-CoV-2 infection, is associated with a plethora of immune-mediated and autoimmune phenomena. A great percentage of infected patients develop autoantibodies, even in the case of non severe disease, raising the issue as to whether those autoantibodies are the forerunners of early autoimmune diseases. Also, COVID-19 patients develop de-novo organ and non-organ immune-mediated manifestations, some of which are evolving into full blown autoimmune diseases, which require immunomodulatory treatments. This issue will tackle this topic and will discuss pathogenic and pathophysiological mechanisms which link the virus with autoimmune manifestations which will assist efforts of experimental and translational research to understand the origin of the documented link.

Submission deadline: 30 October 2023

Journal Cover

January-February 2023
Volume 5 Issue 1

Print ISSN: 2632-2900
Online ISSN: 2632-2919

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