Serum adiponectin and leptin in young healthy men: Preliminary data from a small pilot cohort

Alassiri,Mohammed; Alhomaidhi,Joud; Alrfaei,Bahauddeen M.; Abdullah,Mashan L.

doi:10.3892/wasj.2026.473

July-August 2026 Volume 8 Issue 4

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July-August 2026 Volume 8 Issue 4

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Serum adiponectin and leptin in young healthy men: Preliminary data from a small pilot cohort

Authors:
- Mohammed Alassiri
- Joud Alhomaidhi
- Bahauddeen M. Alrfaei
- Mashan L. Abdullah
View Affiliations / Copyright

Affiliations: Department of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences (KSAU‑HS), King Abdullah International Medical Research Center (KAIMRC), Riyadh 11481, Kingdom of Saudi Arabia, Department of Cellular Therapy and Cancer Research, King Abdullah International Medical Research Center (KAIMRC), King Saud bin Abdulaziz University for Health Sciences (KSAU‑HS), Ministry of National Guard‑Health Affairs (MNGHA), Riyadh 11481, Kingdom of Saudi Arabia, Department of Experimental Medicine, King Abdullah International Medical Research Center (KAIMRC), King Saud bin Abdulaziz University for Health Sciences (KSAU‑HS), Ministry of National Guard‑Health Affairs (MNGHA), Riyadh 11481, Kingdom of Saudi Arabia

Copyright: © Alassiri et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 58
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Published online on: May 11, 2026

https://doi.org/10.3892/wasj.2026.473
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Abstract

Adiponectin and leptin are adipokines involved in metabolic regulation and inflammatory signaling. Despite the high burden of metabolic disease, locally generated data remain limited. The present descriptive pilot feasibility study was conducted to generate preliminary assay‑specific serum adiponectin and leptin data in young men and to inform the design of larger standardized studies. In the present study, serum adiponectin and leptin levels were measured in 10 healthy young men. The study participants had a mean age of 28.4±10.1 years, a median age of 23.5 years, an age range of 20‑45 years, and a mean body mass index of 23.1±5.4 kg/m2. Serum adiponectin and leptin levels were measured using commercial Quantikine ELISA kits, and the data were analyzed descriptively. Preliminary descriptive analysis revealed a mean serum adiponectin level of 31.2 ng/ml (0.0312 µg/ml); range, 16.1‑46.4 ng/ml (0.0161‑0.0464 µg/ml) and a mean serum leptin level of 681.6 pg/ml (0.6816 ng/ml); range, 353.7‑1045.8 pg/ml (0.3537‑1.0458 ng/ml). On the whole, the present pilot feasibility study provides preliminary assay‑specific serum adiponectin and leptin data in a small cohort of apparently healthy men. Larger, methodologically standardized studies are warranted to establish robust population‑specific reference data.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Serum adiponectin and leptin in young healthy men: Preliminary data from a small pilot cohort

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