Role of viruses in glioblastoma oncogenesis and progression (Review)

Sabri,Imane; Marcinkiewicz,Pawel; Ismaili,Nabil; Abounader,Roger; Chaoui,Imane; Guessous,Fadila

doi:10.3892/wasj.2026.502

September-October 2026 Volume 8 Issue 5

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September-October 2026 Volume 8 Issue 5

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Review Open Access

Role of viruses in glioblastoma oncogenesis and progression (Review)

Authors:
- Imane Sabri
- Pawel Marcinkiewicz
- Nabil Ismaili
- Roger Abounader
- Imane Chaoui
- Fadila Guessous
View Affiliations / Copyright

Affiliations: Laboratory of Onco‑Pathology, Biology and Cancer Environment, Faculty of Medicine, Mohammed VI University of Health Sciences, 82403 Casablanca, Morocco, Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22904, USA, Unit of Biology and Medical Research, National Energy Center of Nuclear Science and Technology, 10080 Rabat, Morocco

Copyright: © Sabri et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 87
|
Published online on: August 26, 2026

https://doi.org/10.3892/wasj.2026.502
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Abstract

Glioblastoma (GBM) is a frequent primary brain tumor well‑known for its poor prognosis. The underlying cause of this malignancy has not yet been clarified. To date, the only determined risk factors are ionizing radiation exposure and some inherited genetic syndromes. Since a number of viruses have been implicated in the development of cancer, an investigation into of the viral etiology of GBM was conducted. Numerous exogenous viruses, from the herpesvirus and polyomavirus families, have been detected in GBM tissue samples and despite their prevalence being inconsistent across studies, human cytomegalovirus (CMV) has previously been associated with GBM progression and has also been suggested to serve a direct role in gliomagenesis, as CMV‑elicited GBM cells are generated from normal astrocytes. Furthermore, endogenous retroviruses integrated into the human genome, such as human mouse mammary tumor virus‑like‑2 and human endogenous retrovirus W, can also contribute to certain oncogenic pathways, leading to poor clinical outcomes. Overall, a deeper understanding of how these viruses interact with their hosts could pave the way for new preventive strategies and the identification of new therapeutic targets.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Role of viruses in glioblastoma oncogenesis and progression (Review)

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Abstract

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