Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta‑analysis

  • Authors:
    • Yanqun Xiang
    • Hua Zeng
    • Xiang Liu
    • Hui Zhou
    • Ling Luo
    • Chaohui Duan
    • Xiaohong Luo
    • Haiyan Yan
  • View Affiliations

  • Published online on: May 28, 2013     https://doi.org/10.3892/br.2013.114
  • Pages: 629-637
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Abstract

Thymidine kinase 1 (TK1) is an enzyme involved in nucleic acid synthesis and is therefore considered to be an important tumor proliferation marker. The aim of the present study was to determine the diagnostic role of TK1 measurement in cancer. An extensive electronic search was performed in PubMed, EMBASE and the Cochrane Library using the keywords ‘thymidine kinase 1’ and ‘tumor’ and synonyms. this study was conducted as part of a project to establish evidence‑based guidelines for the diagnosis and treatment of cancer. A total of 453 abstracts were screened, after which the full text of 40 studies were selected for further investigation, including screening of the references cited by studies in the original search. Fifteen studies were enrolled following full‑text evaluation. The areas under the receiver operating characteristic curves for the radioenzymatic assay (REA), the chemiluminescence immunoassay (CLIA) and the total were 0.88, 0.75 and 0.8, respectively. These results were all between <0.9 and >0.7, which suggested a moderate diagnostic efficacy. The positive likelihood ratio of the CLIA method was the highest (10.229), which demonstrated that CLIA exhibited a satisfactory specificity in tumor diagnosis. However, TK1 as a single diagnostic tumor marker was not of significant value and the combination of more tumor markers in the diagnosis of tumors may be preferable.
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July-August 2013
Volume 1 Issue 4

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Online ISSN:2049-9442

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Spandidos Publications style
Xiang Y, Zeng H, Liu X, Zhou H, Luo L, Duan C, Luo X and Yan H: Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta‑analysis. Biomed Rep 1: 629-637, 2013
APA
Xiang, Y., Zeng, H., Liu, X., Zhou, H., Luo, L., Duan, C. ... Yan, H. (2013). Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta‑analysis. Biomedical Reports, 1, 629-637. https://doi.org/10.3892/br.2013.114
MLA
Xiang, Y., Zeng, H., Liu, X., Zhou, H., Luo, L., Duan, C., Luo, X., Yan, H."Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta‑analysis". Biomedical Reports 1.4 (2013): 629-637.
Chicago
Xiang, Y., Zeng, H., Liu, X., Zhou, H., Luo, L., Duan, C., Luo, X., Yan, H."Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta‑analysis". Biomedical Reports 1, no. 4 (2013): 629-637. https://doi.org/10.3892/br.2013.114