Arachis hypogaea L. stem and leaf extract improves the sleep behavior of pentobarbital‑treated rats

  • Authors:
    • Xiao‑Yan Zu
    • Guang‑Quan Xiong
    • Sheng‑Rong Geng
    • Tao Liao
    • Xin Li
    • Zhen‑Ya Zhang
  • View Affiliations

  • Published online on: March 19, 2014     https://doi.org/10.3892/br.2014.259
  • Pages: 388-391
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Abstract

This study was conducted to evaluate the sedative effects of Arachis hypogaea L. stem and leaf extract (AHSLE) and determine its effect pathways through γ‑aminobutyric acid (GABA)‑gated channels on male Sprague‑Dawley rats treated with pentobarbital. AHSLE was obtained from 98˚C water (3 h, extracted twice). AHSLE and flumazenil (a GABA type A receptor antagonist) were administered to the rats orally, whereas pentobarbital sodium and muscimol (a GABA type A receptor agonist) were administered intraperitoneally (i.p.). The results demonstrated that AHSLE decreased sleep latency and increased sleep time in pentobarbital‑treated rats (50 mg/kg, i.p.). The coadministration of AHSLE and muscimol (0.05 mg/kg) significantly increased sleep time and reduced sleep latency in pentobarbital‑treated rats and these actions were significantly antagonized by flumazenil at a dose of 3.5 mg/kg. These results indicated that AHSLE improved the sleep behavior in pentobarbital‑treated rats, possibly through GABA‑gated channel-related mechanisms.
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May-June 2014
Volume 2 Issue 3

Print ISSN: 2049-9434
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Spandidos Publications style
Zu XY, Xiong GQ, Geng SR, Liao T, Li X and Zhang ZY: Arachis hypogaea L. stem and leaf extract improves the sleep behavior of pentobarbital‑treated rats. Biomed Rep 2: 388-391, 2014
APA
Zu, X., Xiong, G., Geng, S., Liao, T., Li, X., & Zhang, Z. (2014). Arachis hypogaea L. stem and leaf extract improves the sleep behavior of pentobarbital‑treated rats. Biomedical Reports, 2, 388-391. https://doi.org/10.3892/br.2014.259
MLA
Zu, X., Xiong, G., Geng, S., Liao, T., Li, X., Zhang, Z."Arachis hypogaea L. stem and leaf extract improves the sleep behavior of pentobarbital‑treated rats". Biomedical Reports 2.3 (2014): 388-391.
Chicago
Zu, X., Xiong, G., Geng, S., Liao, T., Li, X., Zhang, Z."Arachis hypogaea L. stem and leaf extract improves the sleep behavior of pentobarbital‑treated rats". Biomedical Reports 2, no. 3 (2014): 388-391. https://doi.org/10.3892/br.2014.259