Association of the vascular endothelial growth factor ‑2578C/A polymorphism with cancer risk: A meta‑analysis update

  • Authors:
    • Quanchi Chen
    • Zifei Zhou
    • Liangcheng Shan
    • Yingqi Hua
    • Hui Zeng
    • Pengcheng Liu
    • Zhengdong Cai
  • View Affiliations

  • Published online on: July 15, 2014     https://doi.org/10.3892/br.2014.317
  • Pages: 823-830
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Abstract

The vascular endothelial growth factor (VEGF) ‑2578C/A polymorphism has been previously reported to be associated with cancer risk; however, the results have been controversial. Therefore, the aim of the present study was to explore the association between the VEGF ‑2578C/A polymorphism with the cancer risk. A total of 37 case‑control studies were identified. The pooled analysis showed that there was no association between VEGF ‑2578C/A and the risk of cancer, and the odds ratios (ORs) [with the corresponding 95% confidence intervals (95% CIs)] were 0.97 (0.91‑1.04) for C vs. A, 0.94 (0.86‑1.02) for CC vs. AA, 0.92 (0.80‑1.06) for CA vs. AA, 0.96 (0.89‑1.03) for CC/CA vs. AA and 0.97 (0.88‑1.08) for CC vs. CA/AA. Subgroup analyses according to ethnicity, source of control and type of cancer showed that the VEGF ‑2578C/A polymorphism is associated with colorectal and lung cancers. Additionally, the polymorphism may decrease the risk of cancer in the Asian population. This VEGF polymorphism was not associated with a risk of cancer for the Caucasian [0.92 (0.76‑1.11) for CC vs. AA] and African populations [1.31 (0.67‑2.58) for CC vs. AA], and it was not associated with bladder [1.06 (0.74‑1.53) for CC/AA] and breast cancers [1.01 (0.90‑1.15) for CC/AA]. Therefore, the present meta‑analysis indicates that VEGF ‑2578C/A may only be associated with the risk of colorectal cancer, lung cancer and the Asian population. More studies with larger sample sizes are required to provide more conclusive evidence.
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November-December 2014
Volume 2 Issue 6

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Spandidos Publications style
Chen Q, Zhou Z, Shan L, Hua Y, Zeng H, Liu P and Cai Z: Association of the vascular endothelial growth factor ‑2578C/A polymorphism with cancer risk: A meta‑analysis update. Biomed Rep 2: 823-830, 2014
APA
Chen, Q., Zhou, Z., Shan, L., Hua, Y., Zeng, H., Liu, P., & Cai, Z. (2014). Association of the vascular endothelial growth factor ‑2578C/A polymorphism with cancer risk: A meta‑analysis update. Biomedical Reports, 2, 823-830. https://doi.org/10.3892/br.2014.317
MLA
Chen, Q., Zhou, Z., Shan, L., Hua, Y., Zeng, H., Liu, P., Cai, Z."Association of the vascular endothelial growth factor ‑2578C/A polymorphism with cancer risk: A meta‑analysis update". Biomedical Reports 2.6 (2014): 823-830.
Chicago
Chen, Q., Zhou, Z., Shan, L., Hua, Y., Zeng, H., Liu, P., Cai, Z."Association of the vascular endothelial growth factor ‑2578C/A polymorphism with cancer risk: A meta‑analysis update". Biomedical Reports 2, no. 6 (2014): 823-830. https://doi.org/10.3892/br.2014.317