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Serum carcinoembryonic antigen and carbohydrate antigen 19‑9 for prediction of malignancy and invasiveness in intraductal papillary mucinous neoplasms of the pancreas: A meta‑analysis

  • Authors:
    • Weilin Wang
    • Lufei Zhang
    • Linghui Chen
    • Jianfeng Wei
    • Qiang Sun
    • Qingshong Xie
    • Xiaohu Zhou
    • Dongkai Zhou
    • Pengfei Huang
    • Qifan Yang
    • Haiyang Xie
    • Lin Zhou
    • Shusen Zheng

  • View Affiliations

  • Published online on: November 3, 2014     https://doi.org/10.3892/br.2014.376
  • Pages: 43-50
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Abstract

The clinical importance of intraductal papillary mucinous neoplasms (IPMN) of the pancreas has been increasing due to the large number of newly diagnosed cases. A meta‑analysis was used to assess the accuracy of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19‑9 (CA19‑9) for the identification of malignant and invasive IPMN. A literature search of PubMed and Web of Knowledge was conducted. Studies included in the analysis addressed the diagnostic accuracy of serum CEA and CA19‑9 and pooled estimates of sensitivity, specificity, positive‑ and negative‑likelihood ratios (PLR and NLR), diagnostic odds ratio (DOR) and receiver operating characteristic curves were calculated using random‑effects models. Predefined subgroup analysis was performed. Fifteen studies (published between 2001 and 2013) were analyzed, including a total of 1,629 patients. Pooled estimates of CEA in malignant and invasive IPNM prediction were: Pooled sensitivity, 18 and 18%; pooled specificity, 93 and 95%; PLR, 2.83 and 3.54; NLR, 0.89 and 0.89; and DOR, 3.35 and 3.6, respectively. Pooled estimates of CA19‑9 in malignant and invasive IPMN prediction were: Pooled sensitivity, 40 and 52%; pooled specificity, 89 and 88%; PLR, 2.93 and 3.78; NLR, 0.74 and 0.6; and DOR, 4.34 and 6.33, respectively. In conclusion, serum CEA has low sensitivity and high specificity for malignant and invasive IPMN. Serum CA19‑9 is a useful non‑invasive preoperative tool for differentiating between invasive and benign IPMN and should be taken into account in the decision to perform surgery.
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January-February 2015
Volume 3 Issue 1

Print ISSN: 2049-9434
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Spandidos Publications style
Wang W, Zhang L, Chen L, Wei J, Sun Q, Xie Q, Zhou X, Zhou D, Huang P, Yang Q, Yang Q, et al: Serum carcinoembryonic antigen and carbohydrate antigen 19‑9 for prediction of malignancy and invasiveness in intraductal papillary mucinous neoplasms of the pancreas: A meta‑analysis. Biomed Rep 3: 43-50, 2015
APA
Wang, W., Zhang, L., Chen, L., Wei, J., Sun, Q., Xie, Q. ... Zheng, S. (2015). Serum carcinoembryonic antigen and carbohydrate antigen 19‑9 for prediction of malignancy and invasiveness in intraductal papillary mucinous neoplasms of the pancreas: A meta‑analysis. Biomedical Reports, 3, 43-50. https://doi.org/10.3892/br.2014.376
MLA
Wang, W., Zhang, L., Chen, L., Wei, J., Sun, Q., Xie, Q., Zhou, X., Zhou, D., Huang, P., Yang, Q., Xie, H., Zhou, L., Zheng, S."Serum carcinoembryonic antigen and carbohydrate antigen 19‑9 for prediction of malignancy and invasiveness in intraductal papillary mucinous neoplasms of the pancreas: A meta‑analysis". Biomedical Reports 3.1 (2015): 43-50.
Chicago
Wang, W., Zhang, L., Chen, L., Wei, J., Sun, Q., Xie, Q., Zhou, X., Zhou, D., Huang, P., Yang, Q., Xie, H., Zhou, L., Zheng, S."Serum carcinoembryonic antigen and carbohydrate antigen 19‑9 for prediction of malignancy and invasiveness in intraductal papillary mucinous neoplasms of the pancreas: A meta‑analysis". Biomedical Reports 3, no. 1 (2015): 43-50. https://doi.org/10.3892/br.2014.376