Association between vitamin D receptor polymorphisms and haplotypes with pulmonary tuberculosis

Salimi,Saeedeh; Farajian-Mashhadi,Farzaneh; Alavi‑Naini,Roya; Talebian,Golbarg; Narooie-Nejad,Mehrnaz

doi:10.3892/br.2014.402

Association between vitamin D receptor polymorphisms and haplotypes with pulmonary tuberculosis

Authors:
- Saeedeh Salimi
- Farzaneh Farajian-Mashhadi
- Roya Alavi‑Naini
- Golbarg Talebian
- Mehrnaz Narooie-Nejad
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Affiliations: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran, Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran, Department of Genetics, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
Published online on: December 15, 2014 https://doi.org/10.3892/br.2014.402
Pages: 189-194

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Abstract

The vitamin D receptor (VDR) is an important factor in activating immune response in different infectious diseases. The aim of the present study was to investigate the association between the VDR gene polymorphisms and pulmonary tuberculosis (PTB). The case control study was performed on 120 PTB patients and 131 healthy controls. Genetic analysis was performed by polymerase chain reaction and the restriction fragment length polymorphism method. The VDR Fok1 Ff genotype was associated with TB and the risk of PTB was two times higher in individuals with the Ff genotype. A higher frequency of f allele was observed in PTB patients and therefore, the f allele may be a risk factor for PTB susceptibility. There were no associations between the Taq1 and Bsm1 polymorphisms and PTB. In addition, haplotype analysis showed that the f‑T‑B and f‑t‑b haplotypes (Fok1, Taq1 and Bsm1) may have the potential to increase PTB susceptibility. In conclusion, the Ff genotype and f allele of the VDR Fok1 polymorphism were associated with PTB susceptibility. In addition, the f‑T‑B and f‑t‑b haplotypes may be the susceptible haplotypes for PTB.

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