Open Access

Mitochondrial DNA heteroplasmy in human health and disease (Review)

  • Authors:
    • George B. Stefano
    • Richard M. Kream
  • View Affiliations

  • Published online on: February 4, 2016     https://doi.org/10.3892/br.2016.590
  • Pages: 259-262
  • Copyright: © Stefano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The biomedical literature has extensively documented the functional roles of genetic polymorphisms in concert with well‑characterized somatic mutations in the etiology and progression of major metastatic diseases afflicting human populations. Mitochondrial heteroplasmy exists as a dynamically determined co‑expression of inherited polymorphisms and somatic mutations in varying ratios within individual mitochondrial DNA genomes with repetitive patterns of tissue specificity. Mechanistically, carcinogenic cellular processes include profound alterations of normative mitochondrial function, notably dependence on aerobic and anaerobic glycolysis, and aberrant production and release of lactate, according to a classic theory. Within the translational context of human health and disease, the present review discusses the necessity of establishing critical foci designed to probe multiple biological roles of mitochondrial heteroplasmy in cancer biology.
View References

Related Articles

Journal Cover

March 2016
Volume 4 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Stefano, G.B., & Stefano, G.B. (2016). Mitochondrial DNA heteroplasmy in human health and disease (Review). Biomedical Reports, 4, 259-262. https://doi.org/10.3892/br.2016.590
MLA
Stefano, G. B., Kream, R. M."Mitochondrial DNA heteroplasmy in human health and disease (Review)". Biomedical Reports 4.3 (2016): 259-262.
Chicago
Stefano, G. B., Kream, R. M."Mitochondrial DNA heteroplasmy in human health and disease (Review)". Biomedical Reports 4, no. 3 (2016): 259-262. https://doi.org/10.3892/br.2016.590