Cytological diagnosis of Rosai‑Dorfman disease: A case report and revision of the literature

Garza‑Guajardo,Raquel; García‑Labastida,Laura Elvira; Rodríguez‑Sánchez,Iram Pablo; Gómez‑Macías,Gabriela Sofía; Delgado‑Enciso,Iván; Sánchez Chaparro,María Marisela; Barboza‑Quintana,Oralia

doi:10.3892/br.2016.814

Cytological diagnosis of Rosai‑Dorfman disease: A case report and revision of the literature

Authors:
- Raquel Garza‑Guajardo
- Laura Elvira García‑Labastida
- Iram Pablo Rodríguez‑Sánchez
- Gabriela Sofía Gómez‑Macías
- Iván Delgado‑Enciso
- María Marisela Sánchez Chaparro
- Oralia Barboza‑Quintana
View Affiliations

Affiliations: Department of Pathological Anatomy and Cytopathology, University Hospital ‘Dr José Eleuterio González’, Autonomous University of Nuevo León, Monterrey, Nuevo Leon 64460, Mexico, Department of Genetics, School of Medicine, Autonomous University of Nuevo León, Monterrey, Nuevo Leon 64460, Mexico, Universisy of Colima, School of Medicine, Colima 28030, Mexico, Laboratory of Immunology and Virology, Faculty of Biological Sciences, Autonomous University of Nuevo León, San Nicolas de los Garza, Nuevo Leon 66420, Mexico
Published online on: November 18, 2016 https://doi.org/10.3892/br.2016.814
Pages: 27-31
Copyright: © Garza‑Guajardo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Rosai-Dorfman disease also known as sinus histiocytosis with massive lymphadenopathy (SHML) is characterized by distorted lymph node architecture with marked dilation of lymphatic sinuses occupied by numerous lymphocytes, as well as histiocytes with vesicular nucleus and abundant clear cytoplasm with phagocytized lymphocytes or plasma cells, also known as ‘emperipolesis’. This disease of unknown etiology progresses with a benign prognosis strictly and only when an early diagnosis and treatment is made. A late diagnosis and a generalized lymph node involvement contribute to a poor prognosis. In this study, we focussed on the cytological characteristics of the Rosai‑Dorfman disease and differential diagnoses. We reported a case of a 61‑year‑old Mexican male with a 9‑month history of painless bilateral cervical masses and low-grade fever with the final diagnosis of Rosai‑Dorfman disease. The final diagnosis was made by fine needle aspiration (FNA) biopsy of parotid gland and cervical lymph node. In conclusion, FNA biopsy can be enough to make the diagnosis in most cases due to the distinct cytological features of SHML, thereby avoiding more invasive approaches that potentially are unnecessary.

View Figures

View References

1	Foucar E, Rosai J and Dorfman R: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Review of the entity. Semin Diagn Pathol. 7:19–73. 1990.PubMed/NCBI
2	Gaitonde S: Multifocal, extranodal sinus histiocytosis with massive lymphadenopathy: An overview. Arch Pathol Lab Med. 131:1117–1121. 2007.PubMed/NCBI
3	Najafi-Sani M, Saneian H and Mahjoub F: Rosai-Dorfman disease with nodal and extranodal involvements: A case report. J Res Med Sci. 16:1251–1256. 2011.PubMed/NCBI
4	Cocker RS, Kang J and Kahn LB: Rosai-Dorfman disease. Report of a case presenting as a midline thyroid mass. Arch Pathol Lab Med. 127:e197–e200. 2003.PubMed/NCBI
5	Shi Y, Griffin AC, Zhang PJ, Palmer JN and Gupta P: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman Disease): A case report and review of 49 cases with fine needle aspiration cytology. Cytojournal. 8:32011. View Article : Google Scholar : PubMed/NCBI
6	Kumar B, Karki S and Paudyal P: Diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) by fine needle aspiration cytology. Diagn Cytopathol. 36:691–695. 2008. View Article : Google Scholar : PubMed/NCBI
7	Vemuganti GK, Naik MN and Honavar SG: Rosai Dorfman disease of the orbit. J Hematol Oncol. 1:72008. View Article : Google Scholar : PubMed/NCBI
8	Kala C, Agarwal A and Kala S: Extranodal manifestation of Rosai-Dorfman disease with bilateral ocular involvement. J Cytol. 28:131–133. 2011. View Article : Google Scholar : PubMed/NCBI
9	Sandoval-Sus JD, Sandoval-Leon AC, Chapman JR, Velazquez-Vega J, Borja MJ, Rosenberg S, Lossos A and Lossos IS: Rosai-Dorfman disease of the central nervous system: Report of 6 cases and review of the literature. Medicine (Baltimore). 93:165–175. 2014. View Article : Google Scholar : PubMed/NCBI
10	Ruggiero A, Attinà G, Maurizi P, Mulè A, Tarquini E, Barone G, Lazzareschi I and Riccardi R: Rosai-Dorfman disease: Two case reports and diagnostic role of fine-needle aspiration cytology. J Pediatr Hematol Oncol. 28:103–106. 2006. View Article : Google Scholar : PubMed/NCBI
11	Jani PA and Banjan D: A case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman syndrome) from western India. Mcgill J Med. 11:156–159. 2008.PubMed/NCBI
12	Tsang WY, Yip TT and Chan JK: The Rosai-Dorfman disease histiocytes are not infected by Epstein-Barr virus. Histopathology. 25:88–90. 1994. View Article : Google Scholar : PubMed/NCBI
13	Mehraein Y, Wagner M, Remberger K, Füzesi L, Middel P, Kaptur S, Schmitt K and Meese E: Parvovirus B19 detected in Rosai-Dorfman disease in nodal and extranodal manifestations. J Clin Pathol. 59:1320–1326. 2006. View Article : Google Scholar : PubMed/NCBI
14	Arakaki N, Gallo G, Majluf R, Diez B, Arias E, Riudavets MA and Sevlever G: Extranodal rosai-dorfman disease presenting as a solitary mass with human herpesvirus 6 detection in a pediatric patient. Pediatr Dev Pathol. 15:324–328. 2012. View Article : Google Scholar : PubMed/NCBI
15	Ortonne N, Fillet AM, Kosuge H, Bagot M, Frances C and Wechsler J: Cutaneous Destombes-Rosai-Dorfman disease: Absence of detection of HHV-6 and HHV-8 in skin. J Cutan Pathol. 29:113–118. 2002. View Article : Google Scholar : PubMed/NCBI
16	Al-Daraji W, Anandan A, Klassen-Fischer M, Auerbach A, Marwaha JS and Fanburg-Smith JC: Soft tissue Rosai-Dorfman disease: 29 new lesions in 18 patients, with detection of polyomavirus antigen in 3 abdominal cases. Ann Diagn Pathol. 14:309–316. 2010. View Article : Google Scholar : PubMed/NCBI
17	Middel P, Hemmerlein B, Fayyazi A, Kaboth U and Radzun HJ: Sinus histiocytosis with massive lymphadenopathy: Evidence for its relationship to macrophages and for a cytokine-related disorder. Histopathology. 35:525–533. 1999. View Article : Google Scholar : PubMed/NCBI
18	Huang Q, Chang KL and Weiss LM: Extranodal Rosai-Dorfman disease involving the bone marrow: A case report. Am J Surg Pathol. 30:1189–1192. 2006. View Article : Google Scholar : PubMed/NCBI
19	Grabczynska SA, Toh CT, Francis N, Costello C and Bunker CB: Rosai-Dorfman disease complicated by autoimmune haemolytic anaemia: Case report and review of a multisystem disease with cutaneous infiltrates. Br J Dermatol. 145:323–326. 2001. View Article : Google Scholar : PubMed/NCBI
20	Maric I, Pittaluga S, Dale JK, Niemela JE, Delsol G, Diment J, Rosai J, Raffeld M, Puck JM, Straus SE, et al: Histologic features of sinus histiocytosis with massive lymphadenopathy in patients with autoimmune lymphoproliferative syndrome. Am J Surg Pathol. 29:903–911. 2005. View Article : Google Scholar : PubMed/NCBI
21	Juskevicius R and Finley JL: Rosai-Dorfman disease of the parotid gland: Cytologic and histopathologic findings with immunohistochemical correlation. Arch Pathol Lab Med. 125:1348–1350. 2001.PubMed/NCBI
22	Panikar N and Agarwal S: Salivary gland manifestations of sinus histiocytosis with massive lymphadenopathy: Fine-needle aspiration cytology findings. A case report. Diagn Cytopathol. 33:187–190. 2005. View Article : Google Scholar : PubMed/NCBI
23	Pettinato G, Manivel JC, d'Amore ES and Petrella G: Fine needle aspiration cytology and immunocytochemical characterization of the histiocytes in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman syndrome). Acta Cytol. 34:771–777. 1990.PubMed/NCBI
24	Mallick S, Ghosh R, Iyer VK, Jain D and Mathur SR: Cytomorphological and morphometric analysis of 22 cases of Rosai-Dorfman disease: A large series from a tertiary care centre. Acta Cytol. 57:625–632. 2013. View Article : Google Scholar : PubMed/NCBI
25	Deshpande V and Verma K: Fine needle aspiration (FNA) cytology of Rosai Dorfman disease. Cytopathology. 9:329–335. 1998. View Article : Google Scholar : PubMed/NCBI
26	Kushwaha R, Ahluwalia C and Sipayya V: Diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman Disease) by fine needle aspiration cytology. J Cytol. 26:83–85. 2009. View Article : Google Scholar : PubMed/NCBI
27	Zeppa P, Vetrani A, Ciancia G, Cuccuru A and Palombini L: Hemophagocytic histiocytosis diagnosed by fine needle aspiration cytology of the spleen. A case report. Acta Cytol. 48:415–419. 2004. View Article : Google Scholar : PubMed/NCBI
28	Sachdev R and Shyama J: Co-existent Langerhans cell histiocytosis and Rosai-Dorfman disease: A diagnostic rarity. Cytopathology. 19:55–58. 2008.PubMed/NCBI
29	Cozzolino I, Scognamiglio G, Fernandez LV Sosa and Zeppa P: Lymph nodes Fine Needle Cytology in the diagnosis of infectious diseases: Cytological and histological correlations. Infez Med. 20:(Suppl 3). 16–20. 2012.PubMed/NCBI
30	Chhieng DC, Cangiarella JF, Symmans WF and Cohen JM: Fine-needle aspiration cytology of Hodgkin disease: A study of 89 cases with emphasis on false-negative cases. Cancer. 93:52–59. 2001. View Article : Google Scholar : PubMed/NCBI
31	Bangerter M, Brudler O, Heinrich B and Griesshamnuer M: Fine needle aspiration cytology and flow cytometry in the diagnosis and subclassification of non-Hodgkin's lymphoma based on the World Health Organization classification. Acta Cytol. 51:390–398. 2007. View Article : Google Scholar : PubMed/NCBI
32	Zhu F, Zhang JT, Xing XW, Wang DJ, Zhu RY, Zhang Q, Wang HT and Lang SY: Rosai-Dorfman disease: A retrospective analysis of 13 cases. Am J Med Sci. 345:200–210. 2013. View Article : Google Scholar : PubMed/NCBI
33	Córdova Ramos G, González V Machin and Benítez Tang SM: Rosai-Dorfman's disease: A propos of an interesting case study. Acta Otorrinolaringol Esp. 59:311–313. 2008.(In Spanish). View Article : Google Scholar : PubMed/NCBI
34	Chen J, Tang H, Li B and Xiu Q: Rosai-Dorfman disease of multiple organs, including the epicardium: An unusual case with poor prognosis. Heart Lung. 40:168–171. 2011. View Article : Google Scholar : PubMed/NCBI