Open Access

Effect of dark‑colored maple syrup on cell proliferation of human gastrointestinal cancer cell

  • Authors:
    • Tetsushi Yamamoto
    • Kanta Sato
    • Yuika Kubota
    • Kuniko Mitamura
    • Atsushi Taga
  • View Affiliations

  • Published online on: May 16, 2017     https://doi.org/10.3892/br.2017.910
  • Pages: 6-10
  • Copyright: © Yamamoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Maple syrup is a natural sweetener that is commonly consumed worldwide. While maple syrup mainly comprises sucrose, it also contains phytochemicals that present various biological effects. Maple syrup is made by boiling down sap, and its color and composition vary in accordance with the sap collection season. Typically, seasonal progression is associated with darker syrup color, and antioxidant activity is proportional to the increasingly dark color. The authors previously reported that maple syrup demonstrated inhibitory effects on colorectal cancer cell growth and invasion, which correlated with darker maple syrup color. In the present study, they examined the effects of two different grades of maple syrup on gastrointestinal cancer cell proliferation, to investigate whether the dark‑color maple syrup was suitable as a phytomedicine for gastrointestinal cancer treatment. Administration of dark‑color maple syrup significantly inhibited gastrointestinal cancer cell growth as compared to non‑treated cancer cells. Moreover, administration of dark‑color maple syrup clearly inhibited protein kinase B (AKT) phosphorylation and did not impact mitogen‑associated protein kinase phosphorylation. These data suggested that dark‑color maple syrup may inhibit cell proliferation through suppression of AKT activation and, thus, may be suitable as a phytomedicine for gastrointestinal cancer treatment.
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July-2017
Volume 7 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Yamamoto T, Sato K, Kubota Y, Mitamura K and Taga A: Effect of dark‑colored maple syrup on cell proliferation of human gastrointestinal cancer cell. Biomed Rep 7: 6-10, 2017
APA
Yamamoto, T., Sato, K., Kubota, Y., Mitamura, K., & Taga, A. (2017). Effect of dark‑colored maple syrup on cell proliferation of human gastrointestinal cancer cell. Biomedical Reports, 7, 6-10. https://doi.org/10.3892/br.2017.910
MLA
Yamamoto, T., Sato, K., Kubota, Y., Mitamura, K., Taga, A."Effect of dark‑colored maple syrup on cell proliferation of human gastrointestinal cancer cell". Biomedical Reports 7.1 (2017): 6-10.
Chicago
Yamamoto, T., Sato, K., Kubota, Y., Mitamura, K., Taga, A."Effect of dark‑colored maple syrup on cell proliferation of human gastrointestinal cancer cell". Biomedical Reports 7, no. 1 (2017): 6-10. https://doi.org/10.3892/br.2017.910