Open Access

Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography

  • Authors:
    • Lu Gan
    • Cong Feng
    • Chunlei Liu
    • Shuping Tian
    • Xiang Song
    • Li Yang
  • View Affiliations

  • Published online on: May 19, 2016     https://doi.org/10.3892/etm.2016.3371
  • Pages: 667-675
  • Copyright: © Gan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to explore the association between the levels of serum N-terminal pro-B-type natriuretic peptide (NT‑pro BNP) and the characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography (CCTA), in patients with unstable angina (UA). A total of 202 patients (age range, 47‑82 years) were divided into the following three groups: Non‑cardiac disease group (57 patients); stable angina pectoris (SAP) group (62 patients); and UA group (83 patients). There were significant differences between the serum NT‑pro BNP levels among the three groups (P=0.007). However, in multivariant diagnoses, NT‑pro BNP level was not an independent risk factor for UA. The levels of serum NT‑pro BNP were observed to be positively correlated with the number of vessels involved (r=0.462; P<0.001), SIS (r=0.475; P<0.001), segment‑stenosis score (r=0.453; P<0.001), coronary calcification score (r=0.412; P=0.001), number of obstructive diseases (r=0.346; P<0.001), and the number of segments with non‑calcified plaque (r=0.235; P=0.017), mixed plaque (r=0.234; P=0.017) and calcified plaque (r=0.431; P<0.001). The levels of serum NT‑pro BNP were significantly higher in patients with UA and left main‑left anterior descending (LM‑LAD) disease, compared with UA patients without LM‑LAD disease (P<0.001). In addition, serum NT‑pro BNP was significantly higher in patients with obstructive disease and UA than in those without obstructive disease (P<0.001). The area under the curve of log(NT‑pro BNP) was 0.656 (P=0.006; optimal cut‑off value, 1.74; sensitivity, 77.6%; specificity, 51.9%). In conclusion, the levels of serum NT‑pro BNP are associated with the burden and severity of coronary artery atherosclerotic disease in patients with UA, and may be helpful in risk stratification of patients with UA.
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August-2016
Volume 12 Issue 2

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Spandidos Publications style
Gan L, Feng C, Liu C, Tian S, Song X and Yang L: Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography. Exp Ther Med 12: 667-675, 2016
APA
Gan, L., Feng, C., Liu, C., Tian, S., Song, X., & Yang, L. (2016). Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography. Experimental and Therapeutic Medicine, 12, 667-675. https://doi.org/10.3892/etm.2016.3371
MLA
Gan, L., Feng, C., Liu, C., Tian, S., Song, X., Yang, L."Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography". Experimental and Therapeutic Medicine 12.2 (2016): 667-675.
Chicago
Gan, L., Feng, C., Liu, C., Tian, S., Song, X., Yang, L."Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography". Experimental and Therapeutic Medicine 12, no. 2 (2016): 667-675. https://doi.org/10.3892/etm.2016.3371