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Neuronal uptake of serum albumin is associated with neuron damage during the development of epilepsy

  • Authors:
    • Zanhua Liu
    • Jinjie Liu
    • Suping Wang
    • Sibo Liu
    • Yongbo Zhao

  • View Affiliations

  • Published online on: May 26, 2016     https://doi.org/10.3892/etm.2016.3397
  • Pages: 695-701

  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It is well established that brain blood barrier dysfunction following the onset of seizures may lead to serum albumin extravasation into the brain. However, the effect of albumin extravasation on the development of epilepsy is yet to be fully elucidated. Previous studies have predominantly focused on the effect of albumin absorption by astrocytes; however, the present study investigated the effects of neuronal uptake of albumin in vitro and in kainic acid‑induced Sprague‑Dawley rat models of temporal lobe epilepsy. In the present study, electroencephalogram recordings were conducted to record seizure onset, Nissl and Evans blue staining were used to detect neuronal damage and albumin extravasation, respectively, and double immunofluorescence was used to explore neuronal absorption of albumin. Cell counting was also conducted in vitro to determine whether albumin contributes to neuronal death. The results of the present study indicated that extravasated serum albumin was absorbed by neurons, and the neurons that had absorbed albumin died and were dissolved 28 days after seizure onset in vivo. Furthermore, significant neuronal death was detected after albumin absorption in vitro in a dose‑ and time‑dependent manner. These results suggested that albumin may be absorbed by neurons following the onset of seizures. Furthermore, the results indicated that neuronal albumin uptake may be associated with neuronal damage and death in epileptic seizures. Therefore, attenuating albumin extravasation following epileptic seizures may reduce brain damage and slow the development of epilepsy.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu Z, Liu J, Wang S, Liu S and Zhao Y: Neuronal uptake of serum albumin is associated with neuron damage during the development of epilepsy. Exp Ther Med 12: 695-701, 2016
APA
Liu, Z., Liu, J., Wang, S., Liu, S., & Zhao, Y. (2016). Neuronal uptake of serum albumin is associated with neuron damage during the development of epilepsy. Experimental and Therapeutic Medicine, 12, 695-701. https://doi.org/10.3892/etm.2016.3397
MLA
Liu, Z., Liu, J., Wang, S., Liu, S., Zhao, Y."Neuronal uptake of serum albumin is associated with neuron damage during the development of epilepsy". Experimental and Therapeutic Medicine 12.2 (2016): 695-701.
Chicago
Liu, Z., Liu, J., Wang, S., Liu, S., Zhao, Y."Neuronal uptake of serum albumin is associated with neuron damage during the development of epilepsy". Experimental and Therapeutic Medicine 12, no. 2 (2016): 695-701. https://doi.org/10.3892/etm.2016.3397