Open Access

Parameters of diffusional kurtosis imaging for the diagnosis of acute cerebral infarction in different brain regions

  • Authors:
    • Yue‑Lin Guo
    • Su‑Juan Li
    • Zhong‑Ping Zhang
    • Zhi‑Wei Shen
    • Gui‑Shan Zhang
    • Gen Yan
    • Yan‑Ting Wang
    • Hai‑Bing Rao
    • Wen‑Bin Zheng
    • Ren‑Hua Wu
  • View Affiliations

  • Published online on: May 25, 2016     https://doi.org/10.3892/etm.2016.3390
  • Pages: 933-938
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diffusional kurtosis imaging (DKI) is a new type diffusion-weighted sequence which measures the non-Gaussianity of water diffusion. The present study aimed to investigate whether the parameters of DKI could distinguish between differences in water molecule diffusion in various brain regions under the conditions of acute infarction and to identify the optimal DKI parameter for locating ischemic lesions in each brain region. A total of 28 patients with acute ischemic stroke in different brain regions were recruited for the present study. The relative values of DKI parameters were selected as major assessment indices, and the homogeneity of background image and contrast of adjacent structures were used as minor assessment indices. According to the brain region involved in three DKI parametric maps, including mean kurtosis (MK), axial kurtosis (Ka) and radial kurtosis (Kr), 112 groups of regions of interest were outlined in the following regions: Corpus callosum (n=17); corona radiata (n=26); thalamus (n=21); subcortical white matter (n=24); and cerebral cortex (n=24). For ischemic lesions in the corpus callosum and corona radiata, significant increases in relative Ka were detected, as compared with the other parameters (P<0.05). For ischemic lesions in the thalamus, subcortical white matter and cerebral cortices, an increase in the three parameters was detected, however this difference was not significant. Minor assessment indices demonstrated that Ka lacked tissue contrast and the background of Kr was heterogeneous; thus, MK was the superior assessment parameter for ischemic lesions in these regions. In conclusion, Ka is better suited for the diagnosis of acute ischemic lesions in highly anisotropic brain regions, such as the corpus callosum and corona radiate. MK may be appropriate for the lesions in low anisotropic or isotropic brain regions, such as the thalamus, subcortical white matter and cerebral cortices.

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August-2016
Volume 12 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Guo YL, Li SJ, Zhang ZP, Shen ZW, Zhang GS, Yan G, Wang YT, Rao HB, Zheng WB, Wu RH, Wu RH, et al: Parameters of diffusional kurtosis imaging for the diagnosis of acute cerebral infarction in different brain regions. Exp Ther Med 12: 933-938, 2016
APA
Guo, Y., Li, S., Zhang, Z., Shen, Z., Zhang, G., Yan, G. ... Wu, R. (2016). Parameters of diffusional kurtosis imaging for the diagnosis of acute cerebral infarction in different brain regions. Experimental and Therapeutic Medicine, 12, 933-938. https://doi.org/10.3892/etm.2016.3390
MLA
Guo, Y., Li, S., Zhang, Z., Shen, Z., Zhang, G., Yan, G., Wang, Y., Rao, H., Zheng, W., Wu, R."Parameters of diffusional kurtosis imaging for the diagnosis of acute cerebral infarction in different brain regions". Experimental and Therapeutic Medicine 12.2 (2016): 933-938.
Chicago
Guo, Y., Li, S., Zhang, Z., Shen, Z., Zhang, G., Yan, G., Wang, Y., Rao, H., Zheng, W., Wu, R."Parameters of diffusional kurtosis imaging for the diagnosis of acute cerebral infarction in different brain regions". Experimental and Therapeutic Medicine 12, no. 2 (2016): 933-938. https://doi.org/10.3892/etm.2016.3390