Open Access

Association between chloride-rich versus chloride-restrictive intravenous fluid administration and acute kidney injury in cardiovascular patients in ICU wards

  • Authors:
    • Xudong Wang
    • Chao Zhang
    • Guangsu Huang
    • Dahe Han
    • Xiaoyan Meng
    • Yi Guo
    • Chen Kan
  • View Affiliations

  • Published online on: June 6, 2016     https://doi.org/10.3892/etm.2016.3431
  • Pages: 987-990
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the study was to investigate the therapeutic effect of chloride-restrictive fluid to prevent acute kidney injury (AKI) in cardiovascular patients in intensive care unit (ICU) wards. Between January 2013 and September 2014, 456 patients admitted to ICU wards following diagnosis of cardiovascular disease were recruited and randomized to receive chloride-rich (232 patients) or chloride-restrictive (224 patients) fluid. The baseline characteristics and incidence of Kidney Disease Improving Global Outcomes (KDIGO)‑defined AKI was then compared. No significant difference was identified in the baseline characteristics between the two groups. The incidence of moderate-to-severe KDIGO-defined AKI was significantly decreased in patients who received chloride‑restrictive fluid. In conclusion, chloride‑restrictive may be a novel effective intervention in preventing KDIGO-defined AKI in cardiovascular patients in ICU wards.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang X, Zhang C, Huang G, Han D, Meng X, Guo Y and Kan C: Association between chloride-rich versus chloride-restrictive intravenous fluid administration and acute kidney injury in cardiovascular patients in ICU wards. Exp Ther Med 12: 987-990, 2016
APA
Wang, X., Zhang, C., Huang, G., Han, D., Meng, X., Guo, Y., & Kan, C. (2016). Association between chloride-rich versus chloride-restrictive intravenous fluid administration and acute kidney injury in cardiovascular patients in ICU wards. Experimental and Therapeutic Medicine, 12, 987-990. https://doi.org/10.3892/etm.2016.3431
MLA
Wang, X., Zhang, C., Huang, G., Han, D., Meng, X., Guo, Y., Kan, C."Association between chloride-rich versus chloride-restrictive intravenous fluid administration and acute kidney injury in cardiovascular patients in ICU wards". Experimental and Therapeutic Medicine 12.2 (2016): 987-990.
Chicago
Wang, X., Zhang, C., Huang, G., Han, D., Meng, X., Guo, Y., Kan, C."Association between chloride-rich versus chloride-restrictive intravenous fluid administration and acute kidney injury in cardiovascular patients in ICU wards". Experimental and Therapeutic Medicine 12, no. 2 (2016): 987-990. https://doi.org/10.3892/etm.2016.3431