The association between the levels of CRP, IL-10, PLA2, Fbg and prognosis in traumatic fracture of lower limb

Jiao,Jing; Wang,Jun-Wen; Xiao,Fei; Huang,Yu-Cheng

doi:10.3892/etm.2016.3746

The association between the levels of CRP, IL-10, PLA2, Fbg and prognosis in traumatic fracture of lower limb

Authors:
- Jing Jiao
- Jun-Wen Wang
- Fei Xiao
- Yu-Cheng Huang
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Affiliations: Department of Orthopedics, Wuhan Pu'ai Hospital, Wuhan, Hubei 430034, P.R. China
Published online on: September 23, 2016 https://doi.org/10.3892/etm.2016.3746
Pages: 3209-3212
Copyright: © Jiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to examine changes of sera levels of C-reactive protein (CRP), interleukin-10 (IL-10), phospholipase A2 (PLA2) and fibrinogen β polypeptide chain gene (Fbg) in patients with traumatic fracture of lower limb, and to evaluate their association with prognosis. The changes in sera levels of CRP, IL-10, PLA2 and Fbg were observed at the time of injury, 24 h, and 5 and 7 days after surgery in 90 patients with traumatic fracture of lower limb. In addition, 50 cases, who presented for health examination, were included as the normal controls. The expression of sera levels of CRP, IL-10, PLA2 and Fbg in patients with traumatic fracture of lower limb, was markedly higher than that in the normal controls prior to surgery (P<0.05). The concentration of CRP significantly increased within 24 h after emergency, but decreased gradually as the wound healed, compared to the controls. Pre‑ and postoperative IL-10 levels increased within 24 h and then decreased gradually. The level of PLA2 in patients before and after surgery was increased, and then decreased gradually. The level of Fbg in patients with trauma was increased after 24 h and then decreased, and increased gradually. The correlation of serum CRP and IL-10 levels (r=0.634, P<0.05), and that of PLA2 and IL-10 levels (r=0.617, P<0.05) were positive. In conclusion, the expression of CRP, IL-10, PLA2 and Fbg levels in traumatic fracture of lower limb markedly increased and was closely associated with prognosis. CRP, IL-10, PLA2 and Fbg levels may therefore serve as useful indexes in determining the progression and prognosis of patients with traumatic fracture of lower limb.

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