Open Access

Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement

  • Authors:
    • Jiguang Jia
    • Hao Peng
    • Sen Chen
  • View Affiliations

  • Published online on: February 6, 2017     https://doi.org/10.3892/etm.2017.4100
  • Pages: 1343-1346
  • Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study investigated the value of human β-defensin 3 (HBD-3) in adjusting the immunity and inflammatory response of T lymphocytes in the body after knee replacement. Sixty-four cases of knee replacement patients were successively selected and randomly divided into the control group and the observation group each with 32 cases. Once a day, for 7 days, patients in the control group were injected with placebo saline solution in the articular cavity. Levels of Th1 and/Th2, interleukin (IL)-2 and IL-10, tumor necrosis factor (TNF)-α, toll-like receptor (TLR)-4, and alkaline phosphatase (ALP) were compared one month later, and implant infection rates were compared within 1-year follow‑up. Compared with patients in the control group, the levels of Th1 and Th1/Th2 in the observation group significantly increased, yet their Th2 decreased. The levels of IL-2 and TNF-α were also observed to be significantly elevated, yet IL-10 decreased. Furthermore, their TLR-4 and ALP levels were significantly higher. Three cases of implant‑related infection occurred in the control group and 1 case in the observation group. In conclusion, HBD-3 could adjust the immunity and inflammatory response of cells in the body after knee replacement, possibly playing an important role in implant-related infection.
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April-2017
Volume 13 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Jia J, Peng H and Chen S: Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement. Exp Ther Med 13: 1343-1346, 2017
APA
Jia, J., Peng, H., & Chen, S. (2017). Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement. Experimental and Therapeutic Medicine, 13, 1343-1346. https://doi.org/10.3892/etm.2017.4100
MLA
Jia, J., Peng, H., Chen, S."Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement". Experimental and Therapeutic Medicine 13.4 (2017): 1343-1346.
Chicago
Jia, J., Peng, H., Chen, S."Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1343-1346. https://doi.org/10.3892/etm.2017.4100