Inhalative and intravenous stimulation of soluble guanylate cyclase reduces pulmonary vascular resistance and increases cardiac output in experimental septic shock

  • Authors:
    • Nils Kronas
    • Birte Peters
    • Hans Peter Richter
    • Alwin Eduard Goetz
    • Jens Christian Kubitz
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  • Published online on: February 21, 2017     https://doi.org/10.3892/etm.2017.4149
  • Pages: 1369-1375
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Abstract

The effects of inhaled and intravenous application of a guanylate cyclase stimulator (BAY 41-8543) on pulmonary vascular resistance (PVR) and cardiac output (CO) were investigated in an experimental model of septic shock. Following induction of septic shock, anaesthetized pigs (n=31) were randomly place into two groups receiving different interventions. Animals in the first group received intravenous BAY 41-8543 (0.6 mg), inhalative BAY 41‑8543 (6 mg) or a placebo. In the second group, the dosage of BAY 41‑8543 was increased two‑fold or combined with inhalation of nitric oxide (iNO). Intravenous and inhaled administration of BAY 41‑8543 resulted in a significantly (P<0.05) reduced PVR and increased CO compared with the placebo. Increasing the dosage of BAY 41-8543 or combining it with iNO did not further decrease PVR. The results of the present study indicate that BAY 41‑8543 effectively reduces PVR and increases CO in septic shock, through inhaled or intravenous routes of administration.
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April-2017
Volume 13 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Kronas N, Peters B, Richter HP, Goetz AE and Kubitz JC: Inhalative and intravenous stimulation of soluble guanylate cyclase reduces pulmonary vascular resistance and increases cardiac output in experimental septic shock. Exp Ther Med 13: 1369-1375, 2017
APA
Kronas, N., Peters, B., Richter, H.P., Goetz, A.E., & Kubitz, J.C. (2017). Inhalative and intravenous stimulation of soluble guanylate cyclase reduces pulmonary vascular resistance and increases cardiac output in experimental septic shock. Experimental and Therapeutic Medicine, 13, 1369-1375. https://doi.org/10.3892/etm.2017.4149
MLA
Kronas, N., Peters, B., Richter, H. P., Goetz, A. E., Kubitz, J. C."Inhalative and intravenous stimulation of soluble guanylate cyclase reduces pulmonary vascular resistance and increases cardiac output in experimental septic shock". Experimental and Therapeutic Medicine 13.4 (2017): 1369-1375.
Chicago
Kronas, N., Peters, B., Richter, H. P., Goetz, A. E., Kubitz, J. C."Inhalative and intravenous stimulation of soluble guanylate cyclase reduces pulmonary vascular resistance and increases cardiac output in experimental septic shock". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1369-1375. https://doi.org/10.3892/etm.2017.4149