Anaphylactic shock caused by haemocoagulase injection in China

  • Authors:
    • Haiwei Yang
    • Liming Yang
    • De‑Wang Wang
    • Ji‑Fu Wei
    • Shaoheng He
  • View Affiliations

  • Published online on: February 14, 2017     https://doi.org/10.3892/etm.2017.4121
  • Pages: 1547-1553
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Haemocoagulase injection is a mixture of purified enzymes isolated from the venom of Bothrops atrox, which is used for the prevention and treatment of haemorrhage. It is a relatively safe pharmacological agent that does not require a skin test prior to administration. However, following a literature search, 14 reported cases of anaphylactic shock caused by haemocoagulase injection were identified, including one lethal case in China. Using SDS‑PAGE and protein identification, four primary components in haemocoagulase injection were characterized, including one metalloproteinase, which may be a thromboplastin‑like enzyme, and two serine proteinases, which may be thrombin‑like enzymes. Administering concentrated haemocoagulase injections failed to provoke a positive skin reaction in allergic patients. Basophil activation tests revealed that haemocoagulase injections did not upregulate cluster of differentiation 63 or C‑C chemokine receptor type 3 expression. These findings suggest that haemocoagulase injection may cause fetal anaphylaxis. Although it is difficult to determine a clear conclusion without being able to evaluate the patients that underwent haemocoagulase injection‑induced shock, it is unlikely that the venomous components of haemocoagulase injection cross‑react with common allergens in allergic patients. It is possible that haemocoagulase injection‑induced anaphylaxis is caused by its additive components, such as mannitol and succinylated gelatin.
View Figures
View References

Related Articles

Journal Cover

April-2017
Volume 13 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang H, Yang L, Wang DW, Wei JF and He S: Anaphylactic shock caused by haemocoagulase injection in China. Exp Ther Med 13: 1547-1553, 2017
APA
Yang, H., Yang, L., Wang, D., Wei, J., & He, S. (2017). Anaphylactic shock caused by haemocoagulase injection in China. Experimental and Therapeutic Medicine, 13, 1547-1553. https://doi.org/10.3892/etm.2017.4121
MLA
Yang, H., Yang, L., Wang, D., Wei, J., He, S."Anaphylactic shock caused by haemocoagulase injection in China". Experimental and Therapeutic Medicine 13.4 (2017): 1547-1553.
Chicago
Yang, H., Yang, L., Wang, D., Wei, J., He, S."Anaphylactic shock caused by haemocoagulase injection in China". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1547-1553. https://doi.org/10.3892/etm.2017.4121