Effect of VBC‑1814/7J, a poly‑phytocompound, on a non‑infectious model of pharyngitis

  • Authors:
    • Junji Uemura
    • Ravinder Nagpal
    • Nicola Zerbinati
    • Birbal Singh
    • Massimiliano Marcellino
    • Dheeraj Mohania
    • Francesco Marotta
    • Fang He
    • Antonio Ayala
    • Yasuhiro Kasugai
    • Roberto Catanzaro
  • View Affiliations

  • Published online on: April 12, 2017     https://doi.org/10.3892/etm.2017.4332
  • Pages: 3075-3080
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Abstract

Pharyngitis presents as an inflammation of the oropharynx, and clinical examination often shows evidence of nasopharyngitis. In numerous cases the condition occurs as a self‑limiting illness of non‑infectious aetiology, whose clinical management remains a matter for debate given the inappropriateness of antibiotics, the reported worsening following steroid use and the recent discouragement of the use of Chinese herbal medicine. The aim of the present study was thus to test VBC‑1814/7J, a poly‑phytocompound with known anti‑inflammatory and immune‑response enhancing properties, in an experimental model of non‑infectious pharyngitis. Experimental non‑infectious pharyngitis was induced by applying a pyridine solution to the surface of the pharyngeal mucosa in rats that were either normally fed (group A) or fed VBC‑1814/7J three days prior to and three days subsequent to the induction of pharyngitis (group B). Healthy rats treated with topical saline were used as a control (group C). At time‑points of 0, one hour, one day and three days sacrifices were carried out and microscopic examination, Evans blue (EB) dye extravasation and tissue concentrations of tumour necrosis factor (TNF)‑α, interleukin (IL)‑6 and mRNA of α‑ and β‑defensins were studied. As compared with group C, group A showed significant microscopic damage, EB extravasation, and increases in the levels of TNF‑α and IL‑6, as well as in the mRNA of three defensins (P<0.001) on the third day of observation. VBC‑1814/7J significantly mitigated these microscopic and inflammatory markers while allowing a prompter and wider defensin reaction (P<0.05 vs. group A). These data suggest that VBC‑1814/7J, as demonstrated in earlier studies, has the potential to address non‑infectious pharyngitis in clinical practice.

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June-2017
Volume 13 Issue 6

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Spandidos Publications style
Uemura J, Nagpal R, Zerbinati N, Singh B, Marcellino M, Mohania D, Marotta F, He F, Ayala A, Kasugai Y, Kasugai Y, et al: Effect of VBC‑1814/7J, a poly‑phytocompound, on a non‑infectious model of pharyngitis. Exp Ther Med 13: 3075-3080, 2017
APA
Uemura, J., Nagpal, R., Zerbinati, N., Singh, B., Marcellino, M., Mohania, D. ... Catanzaro, R. (2017). Effect of VBC‑1814/7J, a poly‑phytocompound, on a non‑infectious model of pharyngitis. Experimental and Therapeutic Medicine, 13, 3075-3080. https://doi.org/10.3892/etm.2017.4332
MLA
Uemura, J., Nagpal, R., Zerbinati, N., Singh, B., Marcellino, M., Mohania, D., Marotta, F., He, F., Ayala, A., Kasugai, Y., Catanzaro, R."Effect of VBC‑1814/7J, a poly‑phytocompound, on a non‑infectious model of pharyngitis". Experimental and Therapeutic Medicine 13.6 (2017): 3075-3080.
Chicago
Uemura, J., Nagpal, R., Zerbinati, N., Singh, B., Marcellino, M., Mohania, D., Marotta, F., He, F., Ayala, A., Kasugai, Y., Catanzaro, R."Effect of VBC‑1814/7J, a poly‑phytocompound, on a non‑infectious model of pharyngitis". Experimental and Therapeutic Medicine 13, no. 6 (2017): 3075-3080. https://doi.org/10.3892/etm.2017.4332