Dietary soy isoflavones alleviate dextran sulfate sodium‑induced inflammation and oxidative stress in mice

Wang,Bin; Wu,Cunbing

doi:10.3892/etm.2017.4469

Dietary soy isoflavones alleviate dextran sulfate sodium‑induced inflammation and oxidative stress in mice

Authors:
- Bin Wang
- Cunbing Wu
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Affiliations: Department of Food and Nutritional Engineering, Jiangsu Food and Pharmaceutical Science College, Huaian, Jiangsu 223005, P.R. China, Department of Food Engineering, Jiangsu Polytechnic of Finance and Economics, Huaian, Jiangsu 223005, P.R. China
Published online on: May 18, 2017 https://doi.org/10.3892/etm.2017.4469
Pages: 276-282
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It has been hypothesized that soy isoflavones exhibit anti-oxidative and anti‑inflammatory functions, however, the effects of soy isoflavones on inflammatory bowel diseases remain unknown. Therefore, the present study aimed to investigate the effect and underlying mechanism of dietary soy isoflavones on dextran sulfate sodium (DSS)‑induced colitis. Mice were administered DSS and soy isoflavones, and histomorphometry, oxidative stress, inflammation and intestinal tight junctions were determined. The current study demonstrated that dietary soy isoflavones alleviated DSS‑induced growth suppression, colonic inflammatory response, oxidative stress and colonic barrier dysfunction. DSS treatment was indicated to activate Toll‑like receptor 4 (TRL4) and myeloid differentiation protein 88 (MyD88) in mice, whereas dietary soy isoflavones inhibited Myd88 expression in DSS‑challenged mice. In conclusion, dietary soy isoflavones alleviate DSS‑induced inflammation in mice, which may be associated with enhancing antioxidant function and inhibiting the TLR4/MyD88 signal.

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