EASApprox® skin‑stretching system: A secure and effective method to achieve wound closure

Song,Mingzhi; Zhang,Zhen; Liu,Tao; Liu,Song; Li,Gang; Liu,Zhaochang; Huang,Jingyang; Chen,Song; Li,Linan; Guo,Li; Qiu,Yang; Wan,Jiajia; Liu,Yuejian; Wu,Tao; Wang,Xiaoyong; Lu,Ming; Wang,Shouyu

doi:10.3892/etm.2017.4539

EASApprox® skin‑stretching system: A secure and effective method to achieve wound closure

Authors:
- Mingzhi Song
- Zhen Zhang
- Tao Liu
- Song Liu
- Gang Li
- Zhaochang Liu
- Jingyang Huang
- Song Chen
- Linan Li
- Li Guo
- Yang Qiu
- Jiajia Wan
- Yuejian Liu
- Tao Wu
- Xiaoyong Wang
- Ming Lu
- Shouyu Wang
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Affiliations: Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Central Research Laboratory, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Anesthesia, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, BIOWIM (China), Ltd., Economic & Technological Development Zone, Dalian, Liaoning 116620, P.R. China
Published online on: June 1, 2017 https://doi.org/10.3892/etm.2017.4539
Pages: 531-538
Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Large skin defects are commonly observed in the clinic and have attracted much attention recently. Therefore, finding an effective solution for large skin defects is a global problem. The objective of the present study was to assess the effectiveness of the EASApprox® skin‑stretching system for closing large skin defects. Skin defects (5x5 cm) were created on the forearms of 9 Bama miniature pigs, which were randomly divided into the following three groups: Direct suture, the new EASApprox® skin‑stretching device and Kirschner wires. Microcirculation was assessed before surgery and after wound closure. Following the different treatments, the defects were sutured, and wound healing was assessed based on a clinical score. Furthermore, microscopic and ultramicroscopic structures were evaluated, including collagen, elastic fibers and the microvessel density. Significant differences in the clinical score and microvessel density were observed among the groups. Additionally, the mean length obtained for elastic fibers was larger than that obtained for the other two groups. Finally, the new EASApprox® skin‑stretching device resulted in successful wound management and with only minor side effects on skin histology and microcirculation. Therefore, this method has the potential to be used for healing large skin defects.

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