Open Access

Effect of α-receptor blockers on lower urinary tract symptoms, sexual function and quality of life in young and middle-aged men with benign prostatic hyperplasia

  • Authors:
    • Tongqing Wang
    • Lei Wang
    • Yalin Liang
    • Jiechang Ju
    • Yi Cai
    • Jie Zhang
    • Hongtao Zhen
    • Yaolei Liu
    • Xiaolong Tang
    • Jizheng Wang
    • Jian Liu
  • View Affiliations

  • Published online on: May 29, 2017     https://doi.org/10.3892/etm.2017.4518
  • Pages: 587-592
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The purpose of the present study was to compare the effectiveness of two common α1-receptor blockers, alfuzosin and tamsulosin, on lower urinary tract symptoms, sexual function, and quality of life in young and middle-aged people with benign prostatic hyperplasia. We recruited 80 young and middle‑aged patients with benign prostatic hyperplasia and divided them into two groups that received either the non-selective α1-receptor blocker alfuzosin or the selective α1A-receptor blocker tamsulosin for 18 consecutive days. After intervention, maximum urinary flow, bladder compliance, maximum detrusor pressure, maximum urethral pressure, 72 h urination frequency and urination frequency at night, average urinary volume, residual urinary volume, urinary symptom distress score were significantly better in the tamsulosin group than in the alfuzosin group. Also, sperm density, sperm motility, sperm activity, and sperm DNA fragmentation index were significantly better in the tamsulosin group compared to the alfuzosin group. Finally, international index of erectile function-5 scores, increased libido and erection, retrograde ejaculation, and the quality of life were significantly better in the tamsulosin group compared to the alfuzosin group. Overall, tamsulosin effectively relieved the lower urinary tract symptoms, improved semen quality, and increased sexual life and quality of life in young and middle‑aged patients with benign prostatic hyperplasia.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wang T, Wang L, Liang Y, Ju J, Cai Y, Zhang J, Zhen H, Liu Y, Tang X, Wang J, Wang J, et al: Effect of α-receptor blockers on lower urinary tract symptoms, sexual function and quality of life in young and middle-aged men with benign prostatic hyperplasia. Exp Ther Med 14: 587-592, 2017
APA
Wang, T., Wang, L., Liang, Y., Ju, J., Cai, Y., Zhang, J. ... Liu, J. (2017). Effect of α-receptor blockers on lower urinary tract symptoms, sexual function and quality of life in young and middle-aged men with benign prostatic hyperplasia. Experimental and Therapeutic Medicine, 14, 587-592. https://doi.org/10.3892/etm.2017.4518
MLA
Wang, T., Wang, L., Liang, Y., Ju, J., Cai, Y., Zhang, J., Zhen, H., Liu, Y., Tang, X., Wang, J., Liu, J."Effect of α-receptor blockers on lower urinary tract symptoms, sexual function and quality of life in young and middle-aged men with benign prostatic hyperplasia". Experimental and Therapeutic Medicine 14.1 (2017): 587-592.
Chicago
Wang, T., Wang, L., Liang, Y., Ju, J., Cai, Y., Zhang, J., Zhen, H., Liu, Y., Tang, X., Wang, J., Liu, J."Effect of α-receptor blockers on lower urinary tract symptoms, sexual function and quality of life in young and middle-aged men with benign prostatic hyperplasia". Experimental and Therapeutic Medicine 14, no. 1 (2017): 587-592. https://doi.org/10.3892/etm.2017.4518