Open Access

iCELLigence real‑time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines (Review)

  • Authors:
    • Leyla Türker Şener
    • Gürcan Albeni̇z
    • Bi̇rcan Di̇nç
    • Işil Albeni̇z
  • View Affiliations

  • Published online on: July 11, 2017     https://doi.org/10.3892/etm.2017.4781
  • Pages: 1866-1870
  • Copyright: © Türker Şener et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The recently developed iCELLigence™ real‑time cell analyzer (RTCA) can be used for the label‑free real‑time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16‑well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity.

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September-2017
Volume 14 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Türker Şener L, Albeni̇z G, Di̇nç B and Albeni̇z I: iCELLigence real‑time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines (Review). Exp Ther Med 14: 1866-1870, 2017
APA
Türker Şener, L., Albeni̇z, G., Di̇nç, B., & Albeni̇z, I. (2017). iCELLigence real‑time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines (Review). Experimental and Therapeutic Medicine, 14, 1866-1870. https://doi.org/10.3892/etm.2017.4781
MLA
Türker Şener, L., Albeni̇z, G., Di̇nç, B., Albeni̇z, I."iCELLigence real‑time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines (Review)". Experimental and Therapeutic Medicine 14.3 (2017): 1866-1870.
Chicago
Türker Şener, L., Albeni̇z, G., Di̇nç, B., Albeni̇z, I."iCELLigence real‑time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines (Review)". Experimental and Therapeutic Medicine 14, no. 3 (2017): 1866-1870. https://doi.org/10.3892/etm.2017.4781