Open Access

Association between potassium channel SNPs and essential hypertension in Xinjiang Kazak Chinese patients

  • Authors:
    • Yuan‑Yuan Han
    • Li‑Jie Wang
    • Liang Zhang
    • Wen‑Wen  Zhang
    • Ke‑Tao Ma
    • Li Li
    • Jun‑Qiang Si
  • View Affiliations

  • Published online on: July 9, 2017     https://doi.org/10.3892/etm.2017.4734
  • Pages: 1999-2006
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to examine whether single‑nucleotide polymorphisms (SNPs) of β1 subunit of large‑conductance Ca2+‑activated K+ channel (KCNMB1) and inwardly rectifying K+ channel, subfamily J, member‑11 (KCNJ11) are associated with essential hypertension (EH) in Xinjiang Kazak Chinese patients. A polymerase chain reaction‑restriction fragment length polymorphism technique was applied to detect the distribution of selected alleles and genotype frequencies in a cohort of Xinjiang Kazak Chinese patients. Samples from 267 patients with EH and 259 normotensive (NT) controls were analyzed. An unconditional logistic regression analysis was used to estimate the odds ratio and 95% confidence interval of the risk factors that are associated with the development of EH. Genotype and allele frequency analyses revealed that the frequency of genotypes KCNJ11‑rs2285676 and KCNMB1‑rs11739136 was not significantly different between the EH and NT groups. Individuals carrying the GG genotype of KCNJ11‑rs5219 had a 2.08 times higher risk of having EH than individuals carrying the GA+AA genotype of KCNJ11‑rs5219. Furthermore, the G allele frequency of KCNJ11‑rs5219 in the EH group was significantly higher than that of the NT group (P=0.048). Additionally, logistic regression analysis revealed that the body weight and GG genotype of KCNJ11‑rs5219 were positively associated with EH in Xinjiang Kazak Chinese patients (P<0.01).

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September-2017
Volume 14 Issue 3

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Spandidos Publications style
Han YY, Wang LJ, Zhang L, Zhang WW, Ma KT, Li L and Si JQ: Association between potassium channel SNPs and essential hypertension in Xinjiang Kazak Chinese patients. Exp Ther Med 14: 1999-2006, 2017
APA
Han, Y., Wang, L., Zhang, L., Zhang, W., Ma, K., Li, L., & Si, J. (2017). Association between potassium channel SNPs and essential hypertension in Xinjiang Kazak Chinese patients. Experimental and Therapeutic Medicine, 14, 1999-2006. https://doi.org/10.3892/etm.2017.4734
MLA
Han, Y., Wang, L., Zhang, L., Zhang, W., Ma, K., Li, L., Si, J."Association between potassium channel SNPs and essential hypertension in Xinjiang Kazak Chinese patients". Experimental and Therapeutic Medicine 14.3 (2017): 1999-2006.
Chicago
Han, Y., Wang, L., Zhang, L., Zhang, W., Ma, K., Li, L., Si, J."Association between potassium channel SNPs and essential hypertension in Xinjiang Kazak Chinese patients". Experimental and Therapeutic Medicine 14, no. 3 (2017): 1999-2006. https://doi.org/10.3892/etm.2017.4734