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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-2017 Volume 14 Issue 3

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article Open Access

Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury

  • Authors:
    • Yanpeng Hou
    • Huai'an Yang
    • Zeshi Cui
    • Xuhui Tai
    • Yanling Chu
    • Xing Guo

  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Science Experiment Center of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Otolaryngology, The 463rd Hospital of The Chinese People's Liberation Army, Shenyang, Liaoning 110042, P.R. China
    Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2461-2468
    |
    Published online on: July 19, 2017
       https://doi.org/10.3892/etm.2017.4804
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Abstract

Obstructive sleep apnea that characterized by chronic intermittent hypoxia (CIH) has been reported to associate with chronic liver injury. Tauroursodeoxycholic acid (TUDCA) exerts liver‑protective effects in various liver diseases. The purpose of this study was to test the hypothesis that TUDCA could protect liver against CIH injury. C57BL/6 mice were subjected to intermittent hypoxia for eight weeks and applied with TUDCA by intraperitoneal injection. The effect of TUDCA on liver histological changes, liver function, oxidative stress, inflammatory response, hepatocyte apoptosis and endoplasmic reticulum (ER) stress were investigated. The results showed that administration of TUDCA attenuated liver pathological changes, reduced serum alanine aminotransferase and aspartate aminotransferase level, suppressed reactive oxygen species activity, decreased tumor necrosis factor‑α and interleukin‑1β level and inhibited hepatocyte apoptosis induced by CIH. TUDCA also inhibited CIH‑induced ER stress in liver as evidenced by decreased expression of ER chaperone 78 kDa glucose-related protein, unfolded protein response transducers and ER proapoptotic proteins. Altogether, the present study described a liver‑protective effect of TUDCA in CIH mice model, and this effect seems at least partly through the inhibition of ER stress.

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Copy and paste a formatted citation
Spandidos Publications style
Hou Y, Yang H, Cui Z, Tai X, Chu Y and Guo X: Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury. Exp Ther Med 14: 2461-2468, 2017.
APA
Hou, Y., Yang, H., Cui, Z., Tai, X., Chu, Y., & Guo, X. (2017). Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury. Experimental and Therapeutic Medicine, 14, 2461-2468. https://doi.org/10.3892/etm.2017.4804
MLA
Hou, Y., Yang, H., Cui, Z., Tai, X., Chu, Y., Guo, X."Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury". Experimental and Therapeutic Medicine 14.3 (2017): 2461-2468.
Chicago
Hou, Y., Yang, H., Cui, Z., Tai, X., Chu, Y., Guo, X."Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2461-2468. https://doi.org/10.3892/etm.2017.4804
Copy and paste a formatted citation
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Spandidos Publications style
Hou Y, Yang H, Cui Z, Tai X, Chu Y and Guo X: Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury. Exp Ther Med 14: 2461-2468, 2017.
APA
Hou, Y., Yang, H., Cui, Z., Tai, X., Chu, Y., & Guo, X. (2017). Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury. Experimental and Therapeutic Medicine, 14, 2461-2468. https://doi.org/10.3892/etm.2017.4804
MLA
Hou, Y., Yang, H., Cui, Z., Tai, X., Chu, Y., Guo, X."Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury". Experimental and Therapeutic Medicine 14.3 (2017): 2461-2468.
Chicago
Hou, Y., Yang, H., Cui, Z., Tai, X., Chu, Y., Guo, X."Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2461-2468. https://doi.org/10.3892/etm.2017.4804
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