Clinical comparative analysis of histidine‑tryptophan‑ketoglutarate solution and St. Thomas crystalloid cardioplegia: A 12‑year study from a single institution

  • Authors:
    • Ying‑Zhong Lin
    • Jing‑Bin Huang
    • Xiang‑Wei Li
    • Xian‑Ming Tang
    • Wei‑Jun Lu
    • Zhao‑Ke Wen
    • Jian Liang
    • Dian‑Yuan Li
    • Hao Wang
  • View Affiliations

  • Published online on: July 19, 2017     https://doi.org/10.3892/etm.2017.4814
  • Pages: 2677-2682
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Abstract

Cardioplegic reperfusion during a long‑term ischemic period interrupts cardiac surgery and increases cellular edema due to repeated administration. The present clinical study compared the protective effects of histidine-ketoglutarate-tryptophan (HTK) solution and St. Thomas crystalloid cardioplegia. Clinical experiences of the myocardial protection induced by one single perfusion with HTK were reviewed in high‑risk patients with severe pulmonary arterial hypertension associated with complex congenital heart disease. This retrospective study included 88 high‑risk patients (aortic cross‑clamp time, >120 min) between March 2001 and July 2012. The cohort was divided into two groups according to the technique used. Either myocardial protection was performed with one single perfusion with HTK solution (HTK group) or with conventional St. Thomas crystalloid cardioplegia (St group). The duration of cardiopulmonary bypass did not differ between the two groups. The mortality, morbidity, intensive care unit (ICU) stay, postoperative hospitalization, and transfusions of HTK group are significantly lower than those of the St group (P<0.05). Univariate and multivariate analysis demonstrated that HTK is a statistically significant independent predictor of decreased early mortality and morbidity (P<0.05). In conclusion, the present findings suggested that HTK solution decreases mortality, morbidity, ICU stay, postoperative hospitalization, and transfusions in high‑risk patients with severe pulmonary arterial hypertension associated with complex congenital heart disease.

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September-2017
Volume 14 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lin YZ, Huang JB, Li XW, Tang XM, Lu WJ, Wen ZK, Liang J, Li DY and Wang H: Clinical comparative analysis of histidine‑tryptophan‑ketoglutarate solution and St. Thomas crystalloid cardioplegia: A 12‑year study from a single institution. Exp Ther Med 14: 2677-2682, 2017.
APA
Lin, Y., Huang, J., Li, X., Tang, X., Lu, W., Wen, Z. ... Wang, H. (2017). Clinical comparative analysis of histidine‑tryptophan‑ketoglutarate solution and St. Thomas crystalloid cardioplegia: A 12‑year study from a single institution. Experimental and Therapeutic Medicine, 14, 2677-2682. https://doi.org/10.3892/etm.2017.4814
MLA
Lin, Y., Huang, J., Li, X., Tang, X., Lu, W., Wen, Z., Liang, J., Li, D., Wang, H."Clinical comparative analysis of histidine‑tryptophan‑ketoglutarate solution and St. Thomas crystalloid cardioplegia: A 12‑year study from a single institution". Experimental and Therapeutic Medicine 14.3 (2017): 2677-2682.
Chicago
Lin, Y., Huang, J., Li, X., Tang, X., Lu, W., Wen, Z., Liang, J., Li, D., Wang, H."Clinical comparative analysis of histidine‑tryptophan‑ketoglutarate solution and St. Thomas crystalloid cardioplegia: A 12‑year study from a single institution". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2677-2682. https://doi.org/10.3892/etm.2017.4814