Open Access

Pathophysiological correlations between fundus fluorescein angiography and optical coherence tomography results in patients with idiopathic epiretinal membranes

  • Authors:
    • Ju Liu
    • Yong Qian
    • Shunnan Yang
    • Li Yan
    • Yi Wang
    • Meng Gao
    • Limei Liu
    • Yuanyuan Xiao
    • Bin Mo
    • Wu Liu
  • View Affiliations

  • Published online on: October 18, 2017     https://doi.org/10.3892/etm.2017.5330
  • Pages:5785-5792
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the current study was to determine the association between fundus fluorescein angiography (FFA) image results, optical coherence tomography (OCT) imaging results and visual functions in patients with idiopathic epiretinal membranes (ERMs). A total of 80 eyes from 40 patients diagnosed with ERM were analyzed. Best‑corrected visual acuity (BCVA) and metamorphopsia were measured using the Early Treatment Diabetic Retinopathy Study eye chart and M‑charts, respectively. Macular thickness and volume were determined using OCT. Macular vascular leakage and distortion, and foveal avascular zone (FAZ) diameters were assessed using FFA. BCVA and M‑chart results confirmed macular degeneration in the affected eyes. The area of macular vascular leakage was positively correlated with macular volume (r=0.50; P=0.001). The ratio of FAZ diameters was negatively correlated with central macular thickness (r=‑0.41; P=0.008). The grade of macular vascular distortion was positively correlated with macular thickness (all r≥0.47; P<0.01) and volume (r=0.53; P<0.001). The results of the current study demonstrated that FFA may effectively identify the degree of changes in retinal macular vasculature. Vascular distortion, measured by FFA, may reflect changes in macular structure and visual functions. These results suggest a potential application of FFA in the pre‑ and post‑surgical evaluation of patients with ERMs.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Liu, J., Qian, Y., Yang, S., Yan, L., Wang, Y., Gao, M. ... Liu, W. (2017). Pathophysiological correlations between fundus fluorescein angiography and optical coherence tomography results in patients with idiopathic epiretinal membranes. Experimental and Therapeutic Medicine, 14, 5785-5792. https://doi.org/10.3892/etm.2017.5330
MLA
Liu, J., Qian, Y., Yang, S., Yan, L., Wang, Y., Gao, M., Liu, L., Xiao, Y., Mo, B., Liu, W."Pathophysiological correlations between fundus fluorescein angiography and optical coherence tomography results in patients with idiopathic epiretinal membranes". Experimental and Therapeutic Medicine 14.6 (2017): 5785-5792.
Chicago
Liu, J., Qian, Y., Yang, S., Yan, L., Wang, Y., Gao, M., Liu, L., Xiao, Y., Mo, B., Liu, W."Pathophysiological correlations between fundus fluorescein angiography and optical coherence tomography results in patients with idiopathic epiretinal membranes". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5785-5792. https://doi.org/10.3892/etm.2017.5330