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Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation

  • Authors:
    • Gerburg Keilhoff
    • Torben Esser
    • Maximilian Titze
    • Uwe Ebmeyer
    • Lorenz Schild
  • View Affiliations / Copyright

    Affiliations: Institute of Biochemistry and Cell Biology, Otto‑von‑Guericke University Magdeburg, Leipziger, D‑39120 Magdeburg, Germany, Department of Anesthesiology, Otto‑von‑Guericke University Magdeburg, Leipziger, D‑39120 Magdeburg, Germany, Department of Pathological Biochemistry, Otto‑von‑Guericke University Magdeburg, Leipziger, D‑39120 Magdeburg, Germany
    Copyright: © Keilhoff et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6034-6046
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    Published online on: October 16, 2017
       https://doi.org/10.3892/etm.2017.5315
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Abstract

Asphyxial cardiac arrest (ACA)‑induced ischemia results in acute and delayed neuronal cell death. The early reperfusion phase is critical for the outcome. Intervention strategies directed to this period are promising to reduce ACA/resuscitation‑dependent impairments. This study focused on the evaluation of the protective potential of an extract from Gynostemma pentaphyllum (GP), a plant used in traditional medicine with antioxidative, glucose lowering and neuroprotective activities, in an ACA rat model. We tested the following parameters: i) Basic systemic parameters such as pCO2 and blood glucose value within the first 30 min post‑ACA; ii) mitochondrial response by determining activities of citrate synthase, respiratory chain complexes I + III and II + III, and the composition of cardiolipin 6 and 24 h post‑ACA; iii) neuronal vitality of the CA1 hippocampal region by immunohistochemistry 24 h and 7 days post‑ACA; and iv) cognitive function by a novel object recognition test 7 days post‑ACA. GP, administered after reaching spontaneous circulation, counteracted the following: i) ACA‑mediated increases in arterial CO2 tension and blood glucose values; ii) transient increase in the activity of the respiratory chain complexes II + III; iii) elevation in cardiolipin content; iv) hippocampal CA1 neurodegeneration, and v) loss of normal novelty‑object seeking. The protective effects of GP were accompanied by side effects of the vehicle DMSO, such as the stimulation of citrate synthase activity in control animals, inhibition of cardiolipin synthesis in ACA animals and complex II + III activity in both control and ACA animals. The results emphasize the importance of the early post‑resuscitation phase for the neurological outcome after ACA/resuscitation, and demonstrated the power of GP substitution as neuroprotective intervention. Moreover, the results underline the need of a careful handling of the popular vehicle DMSO.
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View References

1 

Sims NR and Anderson MF: Mitochondrial contributions to tissue damage in stroke. Neurochem Int. 40:511–526. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Schild L and Reiser G: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+. FEBS J. 272:3593–3601. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Huang L, Applegate PM, Gatling JW, Mangus DB, Zhang J and Applegate RL II: A systematic review of neuroprotective strategies after cardiac arrest: From bench to bedside (part II-comprehensive protection). Med Gas Res. 4:102014. View Article : Google Scholar : PubMed/NCBI

4 

Mangus DB, Huang L, Applegate PM, Gatling JW, Zhang J and Applegate RL II: A systematic review of neuroprotective strategies after cardiac arrest: From bench to bedside (Part I-Protection via specific pathways). Med Gas Res. 4:92014. View Article : Google Scholar : PubMed/NCBI

5 

Sjoberg F and Singer M: The medical use of oxygen: A time for critical reappraisal. J Int Med. 274:505–528. 2013. View Article : Google Scholar

6 

Dell'anna AM, Scolletta S, Donadello K and Taccone FS: Early neuroprotection after cardiac arrest. Curr Opin Crit Care. 20:250–258. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Llitjos JF, Mira JP, Duranteau J and Cariou A: Hyperoxia toxicity after cardiac arrest: What is the evidence? Ann Intensive Care. 6:232016. View Article : Google Scholar : PubMed/NCBI

8 

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, de Ferranti SD, Floyd J, Fornage M, Gillespie C, et al: Heart disease and stroke statistics-2017 Update: A Report From the American Heart Association. Circulation. 135:e146–e603. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Cheng JG: Investigation of the plant jiaogulan and its analogous herb, Wulianmei. Zhong Cao Yao. 21:4241990.

10 

Mishra RN and Joshi D: Jiao Gu Lan (Gynostemma pentaphyllum): The Chinese Rasayan-Current Research Scenario. Int J Res Pharm Biom Sci. 2:1483–1502. 2011.

11 

Chen J: Antistress action of Gynostemma pentaphyllum. Chinese Tradit Patent Med. 11:31–32. 1989.

12 

Shang L, Liu J, Zhu Q, Zhao L, Feng Y, Wang X, Cao W and Xin H: Gypenosides protect primary cultures of rat cortical cells against oxidative neurotoxicity. Brain Res. 1102:163–174. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Norberg A, Hoa NK, Liepinsh E, Van Phan D, Thuan ND, Jörnvall H, Sillard R and Ostenson CG: A novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum. J Biol Chem. 279:41361–41367. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Wang P, Niu L, Gao L, Li WX, Jia D, Wang XL and Gao GD: Neuroprotective effect of gypenosides against oxidative injury in the substantia nigra of a mouse model of Parkinson's disease. J Int Med Res. 38:1084–1092. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Schild L, Roth A, Keilhoff G, Gardemann A and Brödemann R: Protection of hippocampal slices against hypoxia/hypoglycemia injury by a Gynostemma pentaphyllum extract. Phytomedicine. 16:734–743. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Paradies G, Paradies V, Ruggiero FM and Petrosillo G: Cardiolipin and mitochondrial function in health and disease. Antioxid Redox Signal. 20:1925–1953. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Mileykovskaya E and Dowhan W: Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes. Chem Phys Lipids. 179:42–48. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Nakahara I, Kikuchi H, Taki W, Nishi S, Kito M, Yonekawa Y, Goto Y and Ogata N: Changes in major phospholipids of mitochondria during postischemic reperfusion in rat brain. J Neurosurg. 76:244–250. 1992. View Article : Google Scholar : PubMed/NCBI

19 

Ji J, Baart S, Vikulina AS, Clark RS, Anthonymuthu TS, Tyurin VA, Du L, St Croix CM, Tyurina YY, Lewis J, et al: Deciphering of mitochondrial cardiolipin oxidative signaling in cerebral ischemia-reperfusion. J Cereb Blood Flow Metab. 35:319–328. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Schild L, Cotte T, Keilhoff G and Brodemann R: Preconditioning of brain slices against hypoxia induced injury by a Gynostemma pentaphyllum extract-stimulation of anti-oxidative enzyme expression. Phytomedicine. 19:812–818. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Zhang GL, Deng JP, Wang BH, Zhao ZW, Li J, Gao L, Liu BL, Xong JR, Guo XD, Yan ZQ and Gao GD: Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation. Behav Pharmacol. 22:633–644. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Keilhoff G, John R, Langnaese K, Schweizer H and Ebmeyer U: Triggered by asphyxia neurogenesis seems not to be an endogenous repair mechanism, gliogenesis more like it. Neuroscience. 171:869–884. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Keilhoff G, Schweizer H, John R, Langnaese K and Ebmeyer U: Minocycline neuroprotection in a rat model of asphyxial cardiac arrest is limited. Resuscitation. 82:341–349. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Keilhoff G, Titze M, Esser T, Langnaese K and Ebmeyer U: Constitutive and functional expression of YB-1 in microglial cells. Neuroscience. 301:439–453. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Schild L, Chen BH, Makarov P, Kattengell K, Heinitz K and Keilhoff G: Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extract. Phytomedicine. 17:589–597. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Kao TH, Huang SC, Inbaraj BS and Chen BH: Determination of flavonoids and saponins in Gynostemma pentaphyllum (Thunb.) Makino by liquid chromatography-mass spectrometry. Anal Chim Acta. 626:200–211. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Moellering H and Gruber W: Determination of citrate with citrate lyase. Anal Biochem. 17:369–376. 1966. View Article : Google Scholar : PubMed/NCBI

28 

Martens JC, Keilhoff G, Halangk W, Wartmann T, Gardemann A, Päge I and Schild L: Lipidomic analysis of molecular cardiolipin species in livers exposed to ischemia/reperfusion. Mol Cell Biochem. 400:253–263. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254. 1976. View Article : Google Scholar : PubMed/NCBI

30 

Ennaceur A and Delacour J: A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. Behav Brain Res. 31:47–59. 1988. View Article : Google Scholar : PubMed/NCBI

31 

Kandiah P, Ortega S and Torbey MT: Biomarkers and neuroimaging of brain injury after cardiac arrest. Semin Neurol. 26:413–421. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Schummers J and Browning MD: Evidence for a role for GABA(A) and NMDA receptors in ethanol inhibition of long-term potentiation. Brain Res Mol Brain Res. 94:9–14. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Steffensen SC, Nie Z, Criado JR and Siggins GR: Ethanol inhibition of N-methyl-D-aspartate responses involves presynaptic gamma-aminobutyric acid(B) receptors. J Pharmacol Exp Ther. 294:637–647. 2000.PubMed/NCBI

34 

Albertson TE and Joy RM: Increased inhibition in dentate gyrus granule cells following exposure to GABA-uptake blockers. Brain Res. 435:283–292. 1987. View Article : Google Scholar : PubMed/NCBI

35 

Laaris N, Good CH and Lupica CR: Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus. Neuropharmacology. 59:121–127. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Zhang G, Xia F, Zhang Y, Zhang X, Cao Y, Wang L, Liu X, Zhao G and Shi M: Ginsenoside Rd is efficacious against acute ischemic stroke by suppressing microglial proteasome-mediated inflammation. Mol Neurobiol. 53:2529–2540. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Bakar B, Kose EA, Sonal S, Alhan A, Kilinc K and Keskil IS: Evaluation of the neurotoxicity of DMSO infused into the carotid artery of rat. Injury. 43:315–322. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Nurmi J, Boyd J, Anttalainen N, Westerbacka J and Kuisma M: Early increase in blood glucose in patients resuscitated from out-of-hospital ventricular fibrillation predicts poor outcome. Diabetes Care. 35:510–512. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Lokman EF, Gu HF, Mohamud Wan WN and östenson CG: Evaluation of antidiabetic effects of the traditional medicinal plant gynostemma pentaphyllum and the possible mechanisms of insulin release. Evid Based Complement Alternat Med. 2015:1205722015. View Article : Google Scholar : PubMed/NCBI

40 

Hassan M, Sehgal SA and Rashid S: Regulatory cascade of neuronal loss and glucose metabolism. CNS Neurol Disord Drug Targets. 13:1232–1245. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Douglas RM, Ryu J, Kanaan A, Del Carmen Rivero M, Dugan LL, Haddad GG and Ali SS: Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction. Am J Physiol Cell Physiol. 298:C1594–C1602. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Sakonju I, Taura Y, Inayoshi Y, Suzuki T, Takimoto K, Nakaichi M and Nakama S: Cryopreservation of isolated rat islets of Langerhans in the presence of ethylene glycol or dimethyl sulfoxide: Evaluation of toxicity and the dynamic pattern of subsequent insulin release in vitro. Cryobiology. 33:354–362. 1996. View Article : Google Scholar : PubMed/NCBI

43 

Berenguer M, Zhang J, Bruce MC, Martinez L, Gonzalez T, Gurtovenko AA, Xu T, Le Marchand-Brustel Y and Govers R: Dimethyl sulfoxide enhances GLUT4 translocation through a reduction in GLUT4 endocytosis in insulin-stimulated 3T3-L1 adipocytes. Biochimie. 93:697–709. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Yang CM, Lin CC and Hsieh HL: High-glucose-derived oxidative stress-dependent heme oxygenase-1 expression from astrocytes contributes to the neuronal apoptosis. Mol Neurobiol. 54:470–483. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Ye R, Zhao G and Liu X: Ginsenoside Rd for acute ischemic stroke: translating from bench to bedside. Expert Rev Neurother. 13:603–613. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Kim YB, Gidday JM, Gonzales ER, Shah AR and Park TS: Effect of hypoglycemia on postischemic cortical blood flow, hypercapnic reactivity and interstitial adenosine concentration. J Neurosurg. 81:877–884. 1994. View Article : Google Scholar : PubMed/NCBI

47 

Yu LS, Fan YY, Ye G, Li J, Feng XP, Lin K, Dong M and Wang Z: Curcumin alleviates brain edema by lowering AQP4 expression levels in a rat model of hypoxia-hypercapnia-induced brain damage. Exp Ther Med. 11:709–716. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Zhou Y, Li HQ, Lu L, Fu DL, Liu AJ, Li JH and Zheng GQ: Ginsenoside Rg1 provides neuroprotection against blood brain barrier disruption and neurological injury in a rat model of cerebral ischemia/reperfusion through downregulation of aquaporin 4 expression. Phytomedicine. 21:998–1003. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Yu H, Qi GL, Wang J, Chen L, Deng Z, Zhao YS, Lei SS and Zhu XQ: Aquaporin 4 inhibition decreased synthesis of cytokines by acetazolamide in the hippocampus of rats with pentrazol-induced chronic epilepsy. Genet Mol Res. 15:2016. View Article : Google Scholar

50 

Jiang S, Miao B, Song X and Jiang Z: Inactivation of GABA(A) receptor reduces ginsenoside Rb3 neuroprotection in mouse hippocampal slices after oxygen-glucose deprivation. J Ethnopharmacol. 133:914–916. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Zhu JR, Tao YF, Lou S and Wu ZM: Protective effects of ginsenoside Rb(3) on oxygen and glucose deprivation-induced ischemic injury in PC12 cells. Acta Pharmacol Sin. 31:273–280. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Green CR, Botha JA and Tiruvoipati R: Cognitive function, quality of life and mental health in survivors of our-of-hospital cardiac arrest: A review. Anaesth Intensive Care. 43:568–576. 2015.PubMed/NCBI

53 

Popoli M, Yan Z, McEwen BS and Sanacora G: The stressed synapse: The impact of stress and glucocorticoids on glutamate transmission. Nat Rev Neurosci. 13:22–37. 2012.

54 

Takeda A and Tamano H: Proposed glucocorticoid-mediated zinc signaling in the hippocampus. Metallomics. 4:614–618. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Joels M: Functional actions of corticosteroids in the hippocampus. Eur J Pharmacol. 583:312–321. 2008. View Article : Google Scholar : PubMed/NCBI

56 

de Kloet ER, Karst H and Joels M: Corticosteroid hormones in the central stress response: Quick-and-slow. Front Neuroendocrinol. 29:268–272. 2008. View Article : Google Scholar : PubMed/NCBI

57 

Sutt S, Raud S, Abramov U, Innos J, Luuk H, Plaas M, Kõks S, Zilmer K, Mahlapuu R, Zilmer M and Vasar E: Relation of exploratory behaviour to plasma corticosterone and Wfs1 gene expression in Wistar rats. J Psychopharmacol. 24:905–913. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Yuen EY, Liu W, Karatsoreos IN, Ren Y, Feng J, McEwen BS and Yan Z: Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Mol Psychiatry. 16:156–170. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Hoge J and Kesner RP: Role of CA3 and CA1 subregions of the dorsal hippocampus on temporal processing of objects. Neurobiol Learn Mem. 88:225–231. 2007. View Article : Google Scholar : PubMed/NCBI

60 

Vago DR, Bevan A and Kesner RP: The role of the direct perforant path input to the CA1 subregion of the dorsal hippocampus in memory retention and retrieval. Hippocampus. 17:977–987. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Piterkin P, Cole E, Cossette MP, Gaskin S and Mumby DG: A limited role for the hippocampus in the modulation of novel-object preference by contextual cues. Leam Mem. 15:785–791. 2008. View Article : Google Scholar

62 

Zhang G, Zhao Z, Gao L, Deng J, Wang B, Xu D, Liu B, Qu Y, Yu J, Li J and Gao G: Gypenoside attenuates white matter lesions induced by chronic cerebral hypoperfusion in rats. Pharmacol Biochem Behav. 99:42–51. 2011. View Article : Google Scholar : PubMed/NCBI

63 

Hong SW, Yang JH, Joh EH, Kim HJ and Kim DH: Gypenoside TN-2 ameliorates scopolamine-induced learning deficit in mice. J Ethnopharmacol. 134:1010–1013. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Joh EH, Yang JW and Kim DH: Gypenoside LXXIV ameliorates scopolamine-induced learning deficit in mice. Planta Med. 76:793–795. 2010. View Article : Google Scholar : PubMed/NCBI

65 

Hou ST and MacManus JP: Molecular mechanisms of cerebral ischemia-induced neuronal death. Int Rev Cytol. 221:93–148. 2002. View Article : Google Scholar : PubMed/NCBI

66 

Szeto HH: Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury. Antioxid Redox Signal. 10:601–619. 2008. View Article : Google Scholar : PubMed/NCBI

67 

Osborne DM, Pearson-Leary J and McNay EC: The neuroenergetics of stress hormones in the hippocampus and implications for memory. Front Neurosci. 9:1642015. View Article : Google Scholar : PubMed/NCBI

68 

Yu H, Guan Q, Guo L, Zhang H, Pang X, Cheng Y, Zhang X and Sun Y: Gypenosides alleviate myocardial ischemia-reperfusion injury via attenuation of oxidative stress and preservation of mitochondrial function in rat heart. Cell Stress Chaperones. 21:429–437. 2016. View Article : Google Scholar : PubMed/NCBI

69 

Chen DJ, Hu HG, Xing SF, Gao YJ, Xu SF and Piao XL: Metabolic profiling of Gynostemma pentaphyllum extract in rat serum, urine and faeces after oral administration. J Chromatogr B Analyt Technol Biomed Life Sci. 969:42–52. 2014. View Article : Google Scholar : PubMed/NCBI

70 

Nejad KH, Gharib-Naseri MK, Sarkaki A, Dianat M, Badavi M and Farbood Y: Effects of ellagic acid pretreatment on renal functions disturbances induced by global cerebral ischemic-reperfusion in rat. Iran J Basic Med Sci. 20:75–82. 2017.PubMed/NCBI

71 

Filippone SM, Samidurai A, Roh SK, Cain CK, He J, Salloum FN, Kukreja RC and Das A: Reperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK. Oxid Med Cell Longev. 2017:46197202017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Keilhoff G, Esser T, Titze M, Ebmeyer U and Schild L: Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation. Exp Ther Med 14: 6034-6046, 2017.
APA
Keilhoff, G., Esser, T., Titze, M., Ebmeyer, U., & Schild, L. (2017). Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation. Experimental and Therapeutic Medicine, 14, 6034-6046. https://doi.org/10.3892/etm.2017.5315
MLA
Keilhoff, G., Esser, T., Titze, M., Ebmeyer, U., Schild, L."Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation". Experimental and Therapeutic Medicine 14.6 (2017): 6034-6046.
Chicago
Keilhoff, G., Esser, T., Titze, M., Ebmeyer, U., Schild, L."Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6034-6046. https://doi.org/10.3892/etm.2017.5315
Copy and paste a formatted citation
x
Spandidos Publications style
Keilhoff G, Esser T, Titze M, Ebmeyer U and Schild L: Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation. Exp Ther Med 14: 6034-6046, 2017.
APA
Keilhoff, G., Esser, T., Titze, M., Ebmeyer, U., & Schild, L. (2017). Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation. Experimental and Therapeutic Medicine, 14, 6034-6046. https://doi.org/10.3892/etm.2017.5315
MLA
Keilhoff, G., Esser, T., Titze, M., Ebmeyer, U., Schild, L."Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation". Experimental and Therapeutic Medicine 14.6 (2017): 6034-6046.
Chicago
Keilhoff, G., Esser, T., Titze, M., Ebmeyer, U., Schild, L."Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6034-6046. https://doi.org/10.3892/etm.2017.5315
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