Resveratrol alleviates Staphylococcus aureus pneumonia by inhibition of the NLRP3 inflammasome

  • Authors:
    • Suxia Wu
    • Jianan Huang
  • View Affiliations

  • Published online on: October 18, 2017     https://doi.org/10.3892/etm.2017.5337
  • Pages:6099-6104
0

Abstract

Staphylococcus aureus (S. aureus) causes a wide variety of infections, including S. aureus pneumonia. Resveratrol, a natural polyphenolic compound contained in several plant species, exerts various activities, including anti‑bacterial and pulmonary protective activities. The aim of the present study was to evaluate the protective effect of resveratrol on a murine model of S. aureus pneumonia and to elucidate the underlying mechanisms. It was found that resveratrol significantly reduced S. aureus‑induced mortality, ameliorated lung injury and decreased cytokine levels in the bronchoalveolar lavage fluid and lung tissue of S. aureus infected‑mice. In addition, reverse‑transcription quantitative polymerase chain reaction and western blot assays showed that resveratrol markedly decreased the mRNA and protein expression of nucleotide‑binding domain and leucine‑rich repeat containing gene family pyrin domain containing 3 protein (NLRP3), apoptosis‑associated speck‑like protein containing a C‑terminal caspase recruitment domain and caspase‑1. These results demonstrated that resveratrol significantly alleviates S. aureus pneumonia in mice, the possible underlying mechanism of which is associated with the inhibition of the NLRP3 inflammasome. The present study suggested that resveratrol is a potentially useful agent for the treatment of S. aureus pneumonia and S. aureus‑induced infectious diseases.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Wu, S., & Wu, S. (2017). Resveratrol alleviates Staphylococcus aureus pneumonia by inhibition of the NLRP3 inflammasome. Experimental and Therapeutic Medicine, 14, 6099-6104. https://doi.org/10.3892/etm.2017.5337
MLA
Wu, S., Huang, J."Resveratrol alleviates Staphylococcus aureus pneumonia by inhibition of the NLRP3 inflammasome". Experimental and Therapeutic Medicine 14.6 (2017): 6099-6104.
Chicago
Wu, S., Huang, J."Resveratrol alleviates Staphylococcus aureus pneumonia by inhibition of the NLRP3 inflammasome". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6099-6104. https://doi.org/10.3892/etm.2017.5337