Omega‑3 polyunsaturated fatty acids prevent murine dilated cardiomyopathy by reducing oxidative stress and cardiomyocyte apoptosis

  • Authors:
    • Qianxiao Li
    • Qin Yu
    • Rongmei Na
    • Baiting Liu
  • View Affiliations

  • Published online on: October 18, 2017     https://doi.org/10.3892/etm.2017.5338
  • Pages:6152-6158
0

Abstract

Mice that lacked manganese‑superoxide dismutase (Mn‑SOD) activity exhibited the typical pathology of dilated cardiomyopathy (DCM). The aim of the present study was to investigate the effect of supplementation with omega‑3 polyunsaturated fatty acids (n‑3 PUFA) on heart function and oxidative stress biomarkers in mice with DCM. In the present study, heart/muscle‑specific Mn‑SOD‑deficient mice (H/M‑Sod2‑/‑) were treated with n‑3 PUFA (30 mg/kg/day) for 10 weeks, and the reactive oxygen species (ROS) production in their heart mitochondria and cardiac function was subsequently assessed. n‑3 PUFA treatment diminished ROS production and suppressed the progression of cardiac dysfunction. Furthermore, n‑3 PUFA treatment effectively reversed the cardiac dysfunction and dilatation observed in symptomatic H/M‑Sod2‑/‑ mice. Notably, n‑3 PUFA treatment ameliorated a molecular defect in connexin 43. Hematoxylin‑eosin staining indicated that the phenotype of DCM was also ameliorated following n‑3 PUFA treatment. Furthermore, echocardiography demonstrated that cardiac function was significantly improved in the mice treated with n‑3 PUFA (P<0.05). Meanwhile, pre‑treatment with n‑3 PUFA significantly decreased cardiomyocyte apoptosis (P<0.001). In conclusion, n‑3 PUFA treatment is able to prevent murine DCM, primarily by reducing ROS production and improving myocardial apoptosis. Therefore, the impairment of ROS production is proposed as a potential therapy for DCM.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Li, Q., Yu, Q., Na, R., & Liu, B. (2017). Omega‑3 polyunsaturated fatty acids prevent murine dilated cardiomyopathy by reducing oxidative stress and cardiomyocyte apoptosis. Experimental and Therapeutic Medicine, 14, 6152-6158. https://doi.org/10.3892/etm.2017.5338
MLA
Li, Q., Yu, Q., Na, R., Liu, B."Omega‑3 polyunsaturated fatty acids prevent murine dilated cardiomyopathy by reducing oxidative stress and cardiomyocyte apoptosis". Experimental and Therapeutic Medicine 14.6 (2017): 6152-6158.
Chicago
Li, Q., Yu, Q., Na, R., Liu, B."Omega‑3 polyunsaturated fatty acids prevent murine dilated cardiomyopathy by reducing oxidative stress and cardiomyocyte apoptosis". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6152-6158. https://doi.org/10.3892/etm.2017.5338