MicroRNA‑520a suppresses the proliferation and mitosis of HaCaT cells by inactivating protein kinase B

  • Authors:
    • Rui Wang
    • Zigang Zhao
    • Liqiang Zheng
    • Xiaojing Xing
    • Wei Ba
    • Junfen Zhang
    • Min Huang
    • Wenwei Zhu
    • Bing Liu
    • Xianfu Meng
    • Jia Bai
    • Chengxin Li
    • Hengjin Li
  • View Affiliations

  • Published online on: October 17, 2017     https://doi.org/10.3892/etm.2017.5323
  • Pages:6207-6212
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Abstract

Psoriasis is a chronic inflammatory disease of the skin for which an effective treatment strategy remains to be developed. Characteristics of psoriasis include an altered differentiation of keratinocytes and hyperplasia of the skin. The present study aimed to investigate the role served by miR‑520a in psoriasis. The results demonstrated that miR‑520a inhibited the proliferation of HaCaT cells. miR‑520a directly regulated the mRNA and protein expression of its target gene, protein kinase B (AKT). The siRNA silencing of AKT expression in these cells was also evaluated. miRNA‑520a repressed the proliferation and mitotic entry of HaCaT cells, and promoted cell apoptosis. AKT silencing suppressed the proliferation of HaCaT cells. These results suggest that miRNA‑520a regulates the survival of HaCaT cells by inhibiting AKT expression. miRNA‑520a and AKT may therefore be novel targets for the treatment of patients with psoriasis.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Wang, R., Zhao, Z., Zheng, L., Xing, X., Ba, W., Zhang, J. ... Li, H. (2017). MicroRNA‑520a suppresses the proliferation and mitosis of HaCaT cells by inactivating protein kinase B. Experimental and Therapeutic Medicine, 14, 6207-6212. https://doi.org/10.3892/etm.2017.5323
MLA
Wang, R., Zhao, Z., Zheng, L., Xing, X., Ba, W., Zhang, J., Huang, M., Zhu, W., Liu, B., Meng, X., Bai, J., Li, C., Li, H."MicroRNA‑520a suppresses the proliferation and mitosis of HaCaT cells by inactivating protein kinase B". Experimental and Therapeutic Medicine 14.6 (2017): 6207-6212.
Chicago
Wang, R., Zhao, Z., Zheng, L., Xing, X., Ba, W., Zhang, J., Huang, M., Zhu, W., Liu, B., Meng, X., Bai, J., Li, C., Li, H."MicroRNA‑520a suppresses the proliferation and mitosis of HaCaT cells by inactivating protein kinase B". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6207-6212. https://doi.org/10.3892/etm.2017.5323