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Gestational age, not transient hyperthyrotropinemia impacts brain white matter diffusion tensor imaging in premature infants

  • Authors:
    • Pi‑Lien Hung
    • Chun‑Chung Lui
    • Chen‑Chang Lee
    • Yin‑Hsiu Chien
    • Feng‑Shun Chen
    • Chih‑Cheng Chen
    • Hong‑Ren Yu
    • Mei‑Yung Chung
    • Li‑Tung Huang

  • View Affiliations

  • Published online on: November 6, 2017     https://doi.org/10.3892/etm.2017.5440
  • Pages: 1013-1020
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Abstract

Transient hypothyroidism is common in premature infants and increases the risk of adverse neurodevelopmental outcomes. Thyroid hormone (TH) is involved in oligodendrocyte development and myelination, however, whether transient hypothyroidism is associated with oligodendrocyte dysplasia and abnormal myelination is unclear. The aim of the present study was to investigate correlations among TH levels, neurodevelopmental outcomes and white matter (WM) microstructure in premature infants. The authors designed a cohort study recruiting 81 premature infants (age, 23‑35 weeks). A total of 17 were born with a gestational age (GA) <30 weeks (early preterm group) and 64 of them were born with a GA ≥30 weeks (late preterm group). For outcome measurement, thyroid stimulating hormone (TSH) levels at 0, 18, and 24 h of admission were measured. Neurodevelopmental outcomes were assessed using Bayley III test. Diffusion tensor imaging was used to explore the characterization of WM microstructure. The data demonstrated that GA, however not TSH level was associated with neurodevelopmental outcomes in the following 2 years. Fractional anisotrophy (FA) increased with TSH0 levels over anterior limb of internal capsule, while axial diffusivity decreased with TSH0 levels over splenium of corpus callosum (CC). The late preterm group had more intact WM integrity over the internal and external capsule (EC) in FA compared with the early preterm group. Infants with motor dysfunction had significantly increased mean diffusivity (MD) values at regions of interest in the genu and splenium of CC. The results of the present study demonstrated that GA, however not transient hypothyroidism influenced neurodevelopmental outcomes in the premature infants. FA increased with age in a regionally‑specific manner over regions of the internal capsule and EC. MD may act as a potential predictor for motor function in premature babies.
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January-2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hung PL, Lui CC, Lee CC, Chien YH, Chen FS, Chen CC, Yu HR, Chung MY and Huang LT: Gestational age, not transient hyperthyrotropinemia impacts brain white matter diffusion tensor imaging in premature infants. Exp Ther Med 15: 1013-1020, 2018
APA
Hung, P., Lui, C., Lee, C., Chien, Y., Chen, F., Chen, C. ... Huang, L. (2018). Gestational age, not transient hyperthyrotropinemia impacts brain white matter diffusion tensor imaging in premature infants. Experimental and Therapeutic Medicine, 15, 1013-1020. https://doi.org/10.3892/etm.2017.5440
MLA
Hung, P., Lui, C., Lee, C., Chien, Y., Chen, F., Chen, C., Yu, H., Chung, M., Huang, L."Gestational age, not transient hyperthyrotropinemia impacts brain white matter diffusion tensor imaging in premature infants". Experimental and Therapeutic Medicine 15.1 (2018): 1013-1020.
Chicago
Hung, P., Lui, C., Lee, C., Chien, Y., Chen, F., Chen, C., Yu, H., Chung, M., Huang, L."Gestational age, not transient hyperthyrotropinemia impacts brain white matter diffusion tensor imaging in premature infants". Experimental and Therapeutic Medicine 15, no. 1 (2018): 1013-1020. https://doi.org/10.3892/etm.2017.5440