Open Access

The efficacy of homemade tolcapone in the treatment of patients with Parkinson's disease

  • Authors:
    • Pei-Lan Zhang
    • Yu-Xin Wang
    • Yan Chen
    • Chen-Hao Zhang
    • Chen-Hua Li
  • View Affiliations

  • Published online on: October 26, 2017     https://doi.org/10.3892/etm.2017.5377
  • Pages:127-130
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the study was to investigate the efficacy of homemade tolcapone in treatment of patients with Parkinson's disease (PD). Eighty patients with PD were subjected to randomized, double-blind, placebo-controlled and parallel-group study. PD patients were randomly divided into the tolcapone treatment group (41 cases) and placebo group (39 cases). Each patient received 1 pill of tolcapone or placebo, 3 times per day for 26 weeks. Efficacy was evaluated using the internationally used unified Parkinson’s disease rating scale (UPDRS) scoring system for PD symptoms. After the treatment for 26 weeks, the cognitive function, tremor, muscle stiffness, voluntary movement and autonomic nerve symptoms were compared between the two groups using UPDRS scores. Compared with the placebo group, cognitive function, muscle stiffness and voluntary movement reduction were significantly improved in patients of the tolcapone group (P<0.05). However, no significant differences in UPDRS scores of autonomic nerve symptoms and tremor were found between two groups after treatment (P>0.05). Tolcapone, a catechol-O-methyl transferase (COMT) inhibitor, can improve the motor function of patients with PD, especially exercise and muscle stiffness. Tolcapone can also improve the cognitive function of patients.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Zhang, P., Wang, Y., Chen, Y., Zhang, C., & Li, C. (2018). The efficacy of homemade tolcapone in the treatment of patients with Parkinson's disease. Experimental and Therapeutic Medicine, 15, 127-130. https://doi.org/10.3892/etm.2017.5377
MLA
Zhang, P., Wang, Y., Chen, Y., Zhang, C., Li, C."The efficacy of homemade tolcapone in the treatment of patients with Parkinson's disease". Experimental and Therapeutic Medicine 15.1 (2018): 127-130.
Chicago
Zhang, P., Wang, Y., Chen, Y., Zhang, C., Li, C."The efficacy of homemade tolcapone in the treatment of patients with Parkinson's disease". Experimental and Therapeutic Medicine 15, no. 1 (2018): 127-130. https://doi.org/10.3892/etm.2017.5377