Open Access

Açaí (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response

  • Authors:
    • Jianyu Zhou
    • Jianjun Zhang
    • Chun Wang
    • Shengsheng Qu
    • Yingli Zhu
    • Zhihui Yang
    • Linyuan Wang
  • View Affiliations

  • Published online on: November 1, 2017     https://doi.org/10.3892/etm.2017.5427
  • Pages:166-172
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: HTML 0 views | PDF 0 views
0

Abstract

The present study aimed to investigate the therapeutic effects of Euterpe oleracea Mart. (EO) on alcoholic liver diseases (ALD). A total of 30 Wistar rats were randomly divided into three groups (10 rats per group), including alcohol group (alcohol intake), EO group (alcohol + EO puree intake) and control group (distilled water intake). The activity of superoxide dismutase (SOD) and alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the levels of cholesterol (CHO), triglyceride (TG), malondialdehyde (MDA) and glutathione (GSH) in the serum as well as the liver tissue levels of interleukin 8 (IL‑8), tumor necrosis factor‑α (TNF‑α) and transforming growth factor‑β (TGF‑β) were measured. Histopathological changes in liver tissues were observed by hematoxylin and eosin staining. Reverse‑transcription quantitative PCR analysis was performed for detecting the expression of nuclear factor (NF)‑κB and CD68. The results indicated that EO intake significantly decreased ALT, AST, ALP, TG and CHO as well as the hepatic index in alcohol‑treated rats. In addition, EO treatment relieved alcohol‑induced oxidative stress by decreasing the levels of MDA and TG, and increasing the activity of SOD and GSH levels. In addition, the expression of TNF‑α, TGF‑β, IL‑8, NF‑κB and CD‑68 in the liver were decreased by EO treatment. Furthermore, EO intake alleviated the histopathological liver damage, including severe steatosis and abundant infiltrated inflammatory cells. In conclusion, EO alleviated alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response.

Related Articles

Journal Cover

January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Zhou, J., Zhang, J., Wang, C., Qu, S., Zhu, Y., Yang, Z., & Wang, L. (2018). Açaí (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response. Experimental and Therapeutic Medicine, 15, 166-172. https://doi.org/10.3892/etm.2017.5427
MLA
Zhou, J., Zhang, J., Wang, C., Qu, S., Zhu, Y., Yang, Z., Wang, L."Açaí (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response". Experimental and Therapeutic Medicine 15.1 (2018): 166-172.
Chicago
Zhou, J., Zhang, J., Wang, C., Qu, S., Zhu, Y., Yang, Z., Wang, L."Açaí (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response". Experimental and Therapeutic Medicine 15, no. 1 (2018): 166-172. https://doi.org/10.3892/etm.2017.5427