Açaí (Euterpe oleracea Mart.) attenuates alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response
- Jianyu Zhou
- Jianjun Zhang
- Chun Wang
- Shengsheng Qu
- Yingli Zhu
- Zhihui Yang
- Linyuan Wang
Published online on: November 1, 2017
Copyright: © Zhou et al.
This is an open access article distributed under the terms of Creative Commons Attribution License.
The present study aimed to investigate the therapeutic effects of Euterpe oleracea Mart. (EO) on alcoholic liver diseases (ALD). A total of 30 Wistar rats were randomly divided into three groups (10 rats per group), including alcohol group (alcohol intake), EO group (alcohol + EO puree intake) and control group (distilled water intake). The activity of superoxide dismutase (SOD) and alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the levels of cholesterol (CHO), triglyceride (TG), malondialdehyde (MDA) and glutathione (GSH) in the serum as well as the liver tissue levels of interleukin 8 (IL‑8), tumor necrosis factor‑α (TNF‑α) and transforming growth factor‑β (TGF‑β) were measured. Histopathological changes in liver tissues were observed by hematoxylin and eosin staining. Reverse‑transcription quantitative PCR analysis was performed for detecting the expression of nuclear factor (NF)‑κB and CD68. The results indicated that EO intake significantly decreased ALT, AST, ALP, TG and CHO as well as the hepatic index in alcohol‑treated rats. In addition, EO treatment relieved alcohol‑induced oxidative stress by decreasing the levels of MDA and TG, and increasing the activity of SOD and GSH levels. In addition, the expression of TNF‑α, TGF‑β, IL‑8, NF‑κB and CD‑68 in the liver were decreased by EO treatment. Furthermore, EO intake alleviated the histopathological liver damage, including severe steatosis and abundant infiltrated inflammatory cells. In conclusion, EO alleviated alcohol‑induced liver injury in rats by alleviating oxidative stress and inflammatory response.