Open Access

Maternal natural killer cell immunoglobulin receptor genes and human leukocyte antigen-C ligands influence recurrent spontaneous abortion in the Han Chinese population

  • Authors:
    • Ning Su
    • Hongdan Wang
    • Bowei Zhang
    • Yiqing Kang
    • Qiannan Guo
    • Hai Xiao
    • Hecai Yang
    • Shixiu Liao
  • View Affiliations

  • Published online on: October 31, 2017     https://doi.org/10.3892/etm.2017.5406
  • Pages:327-337
  • Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: HTML 0 views | PDF 0 views
0

Abstract

The underlying mechanism of recurrent spontaneous abortion (RSA) has remained elusive for many years. Several previous studies have suggested that the killer cell immunoglobulin receptor (KIR) gene family is associated with RSA, however, it is not clear exactly how. The present study detected KIR and human leukocyte antigen‑C (HLA‑C) genes in 110 Han Chinese women with unexplained RSA and 105 Han Chinese healthy females. The aim of the present study was to determine if certain genotypes were more susceptible to the occurrence of miscarriage. The frequency of KIR genes and different KIR haplotypes in the 2 groups demonstrated no statistical differences. However, in women who had miscarried ≥3 times, the frequency of KIR3DL1 was significantly reduced and the BB haplotype frequency was significantly higher compared with the control group. HLA‑C2C2 was significantly increased in the KIR AB and KIR BB groups in the RSA groups compared with the control group. The women in the RSA group who had a homozygous HLA‑C2C2 had a significantly higher frequency of the 2DS1 gene compared with the control group. The reduction of inhibitory gene and increased activation combinations may induce the activation of uterine natural killer cells, which may reduce the probability of fetal survival. To the best of our knowledge, the present study is the first report demonstrating the association between maternal KIR and HLA‑C genes and RSA in women of a Han Chinese ethnicity. The present study revealed that females who miscarry ≥3 times may be used as selection criteria for RSA and so may exhibit higher research value.

Related Articles

Journal Cover

January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Su, N., Wang, H., Zhang, B., Kang, Y., Guo, Q., Xiao, H. ... Liao, S. (2018). Maternal natural killer cell immunoglobulin receptor genes and human leukocyte antigen-C ligands influence recurrent spontaneous abortion in the Han Chinese population. Experimental and Therapeutic Medicine, 15, 327-337. https://doi.org/10.3892/etm.2017.5406
MLA
Su, N., Wang, H., Zhang, B., Kang, Y., Guo, Q., Xiao, H., Yang, H., Liao, S."Maternal natural killer cell immunoglobulin receptor genes and human leukocyte antigen-C ligands influence recurrent spontaneous abortion in the Han Chinese population". Experimental and Therapeutic Medicine 15.1 (2018): 327-337.
Chicago
Su, N., Wang, H., Zhang, B., Kang, Y., Guo, Q., Xiao, H., Yang, H., Liao, S."Maternal natural killer cell immunoglobulin receptor genes and human leukocyte antigen-C ligands influence recurrent spontaneous abortion in the Han Chinese population". Experimental and Therapeutic Medicine 15, no. 1 (2018): 327-337. https://doi.org/10.3892/etm.2017.5406