Open Access

Protective effect of baicalin on fetal lung development in a rabbit model of congenital diaphragmatic hernia

  • Authors:
    • Hailong Su
    • Linsong Mu
    • Changsheng Liu
  • View Affiliations

  • Published online on: October 31, 2017     https://doi.org/10.3892/etm.2017.5409
  • Pages:61-66
  • Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bacalin has been reported to improve fetal lung growth by increasing fetal lung surfactant phospholipids. Therefore, the present study evaluated the effect of transplacental treatment of baicalin during lung development in rabbits with congenital diaphragmatic hernia (DH) rabbit. DH was induced in fetal rabbit on gestational day 23 and baicalin injections were administered daily until term period. Fetal survival rate, body weight and lung‑to‑body weight ratio (LBWR) were subsequently measured, and the expression of surfactant protein B (SPB) and Ki‑67, and morphometry analysis was determined in lung tissues. It was observed that in baicalin treated group the fetal survival rate and LBWR were decreased compared with the control without DH group. Lung morphometry results suggested that treatment with baicalin did not significantly ameliorate congenital DH, and adventitial and medial thickness were similar to those in the control groups, and less muscularization of vessels measuring 30‑60 µm. Furthermore, baicalin treatment did not markedly affect the expressions of Ki‑67 and SPB in fetuses with DH. Baicalin was demonstrated to improve the morphology of lung in rabbits; however, as it did not induce marked airway changes this present study suggests that baicalin is not suitable for the management of congenital DH.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Su, H., Mu, L., & Liu, C. (2018). Protective effect of baicalin on fetal lung development in a rabbit model of congenital diaphragmatic hernia. Experimental and Therapeutic Medicine, 15, 61-66. https://doi.org/10.3892/etm.2017.5409
MLA
Su, H., Mu, L., Liu, C."Protective effect of baicalin on fetal lung development in a rabbit model of congenital diaphragmatic hernia". Experimental and Therapeutic Medicine 15.1 (2018): 61-66.
Chicago
Su, H., Mu, L., Liu, C."Protective effect of baicalin on fetal lung development in a rabbit model of congenital diaphragmatic hernia". Experimental and Therapeutic Medicine 15, no. 1 (2018): 61-66. https://doi.org/10.3892/etm.2017.5409