Open Access

Pulmonary alveolar microlithiasis: A case report and review of the literature

  • Authors:
    • Xu‑Dong Zhang
    • Jin‑Ming Gao
    • Jin‑Mei Luo
    • Yu Zhao
  • View Affiliations

  • Published online on: November 7, 2017     https://doi.org/10.3892/etm.2017.5457
  • Pages:831-837
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive disease characterized by the formation of calcium phosphate microliths in the alveoli. Mutations in the gene encoding the solute carrier family 34 member 2 gene are considered to be involved in the pathogenesis of PAM. Although PAM can develop in children, the majority of patients with PAM are diagnosed in adulthood due to the slow progressive nature of the disease within the lungs. In childhood, the majority of patients with PAM are asymptomatic and changes in the lung parenchyma are usually identified incidentally. Symptoms of PAM typically appear in the third or fourth decade of life and there is often a notable dissociation between the advanced radiological findings and the mild clinical presentation. A positive diagnosis of PAM is reached by the combination of a positive chest radiograph and histological examination. Genetic testing may help to identify other latent patients in the family of the patient with PAM. In the present study, the cases of 3 patients diagnosed with PAM have been reported, including their clinical presentation, radio imaging, pathological symptoms, genetic test results and treatment plans, as well as the associated literature.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Zhang, X., Gao, J., Luo, J., & Zhao, Y. (2018). Pulmonary alveolar microlithiasis: A case report and review of the literature. Experimental and Therapeutic Medicine, 15, 831-837. https://doi.org/10.3892/etm.2017.5457
MLA
Zhang, X., Gao, J., Luo, J., Zhao, Y."Pulmonary alveolar microlithiasis: A case report and review of the literature". Experimental and Therapeutic Medicine 15.1 (2018): 831-837.
Chicago
Zhang, X., Gao, J., Luo, J., Zhao, Y."Pulmonary alveolar microlithiasis: A case report and review of the literature". Experimental and Therapeutic Medicine 15, no. 1 (2018): 831-837. https://doi.org/10.3892/etm.2017.5457