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Is fetal‑type posterior cerebral artery a risk factor for intracranial aneurysm as analyzed by multislice CT angiography?

  • Authors:
    • Zhen He
    • Yeda Wan
  • View Affiliations

  • Published online on: November 13, 2017     https://doi.org/10.3892/etm.2017.5504
  • Pages:838-846
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fetal‑type posterior cerebral artery (FTP) is a common anatomic variation that is closely associated with intracranial aneurysm. In the present study, multislice computed tomography angiography (CTA) was performed to assess whether FTP is a risk factor for intracranial aneurysm. CTA data of 364 consecutive cases of patients who were suspected with cerebrovascular disease or intracranial aneurysm of intracranial artery from 2013 to 2016 were reviewed and the incidence rates of FTP, other variations of the circle of Willis, intracranial aneurysm and FTP with intracranial aneurysm were evaluated. The χ2 test was used to assess the influence of FTP and gender on the incidence rates of other variations of the circle of Willis, intracranial aneurysm and internal carotid artery‑posterior communicating artery (ICA‑PComA) aneurysm. Binary logistic regression analysis was performed to assess the associations of FTP and gender with intracranial aneurysm and ICA‑PComA aneurysm. Compared with non‑FTP patients, FTP cases exhibited significantly higher rates of other variations of the circle of Willis (χ2=80.173, P<0.001) and ICA‑PComA aneurysm (χ2=4.437, P=0.035). Among patients with FTP and bilateral FTP, more female than male patients with intracranial aneurysm were identified. However, among all patients with intracranial aneurysm, no statistically significant differences in the prevalence of FTP (χ2=2.577, P=0.108) and bilateral FTP (χ2=2.199, P=0.159) between males and females were identified. Binary logistic regression analysis revealed that FTP and gender were risk factors for intracranial aneurysm and ICA‑PComA aneurysm. A moderate association between FTP and ICA‑PComA aneurysm (OR=2.762) were identified, although there was a weak association between FTP and intracranial aneurysm [odds ratio (OR)=1.365]. Furthermore, a strong association was identified between gender and intracranial aneurysm (OR=0.328), and a moderate association existed between gender and ICA‑PComA aneurysm (OR=0.357). In conclusion, female gender is an independent risk factor for intracranial aneurysm, and FTP and female gender are independent risk factors for ICA‑PComA aneurysm.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
He, Z., & He, Z. (2018). Is fetal‑type posterior cerebral artery a risk factor for intracranial aneurysm as analyzed by multislice CT angiography?. Experimental and Therapeutic Medicine, 15, 838-846. https://doi.org/10.3892/etm.2017.5504
MLA
He, Z., Wan, Y."Is fetal‑type posterior cerebral artery a risk factor for intracranial aneurysm as analyzed by multislice CT angiography?". Experimental and Therapeutic Medicine 15.1 (2018): 838-846.
Chicago
He, Z., Wan, Y."Is fetal‑type posterior cerebral artery a risk factor for intracranial aneurysm as analyzed by multislice CT angiography?". Experimental and Therapeutic Medicine 15, no. 1 (2018): 838-846. https://doi.org/10.3892/etm.2017.5504