Open Access

Report and literature review on two cases with different kinds of Creutzfeldt-Jakob disease

  • Authors:
    • Chunhua Tang
    • Changyue Gao
  • View Affiliations

  • Published online on: November 10, 2017     https://doi.org/10.3892/etm.2017.5481
  • Pages:854-858
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Creutzfeldt-Jakob disease (CJD), also known as corticostriate spinal degeneration, subacute spongiform encephalopathy or infectious spongiform encephalopathy, is a type of degenerative disease of the central nervous system caused by prion protein (PrP) infection, which is the most common type of human PrP disease. CJD is genetic and infectious, and is one of the most common causes of rapid progressive dementia with rare clinical occurrence. Herein, we report the clinical conditions of 2 cases of patients with different type of CJD we treated and followed up recently, and a review of relevant literature. The patient in case 1 was admitted due to ‘dizziness with hypomnesis, and mental and behavior disorder’. He was considered to suffer from a central nervous system infection - a viral encephalitis, but one month later, a repeated cranial MRI showed lace sign of bilateral frontotemporal parietal lobe in DWI sequence, an AEEG indicated periodic synchronous discharge, and the detection of cerebrospinal fluid 14-3-3 protein was positive. It was suggested to be diagnosed as the sporadic CJD. The patient in case 2 was admitted because of ‘progressive hypomnesis’. Cerebrospinal fluid 14-3-3 protein detection was negative, but the V203I-related mutation was found in the PRNP gene detection. The patient was suggested to be diagnosed as genetic CJD. Both patients died in a short time. An earlier diagnosis can provide a time window for treatment, and avoid unnecessary transmission in hospital, as well as doctor-patient dispute.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Tang, C., & Tang, C. (2018). Report and literature review on two cases with different kinds of Creutzfeldt-Jakob disease. Experimental and Therapeutic Medicine, 15, 854-858. https://doi.org/10.3892/etm.2017.5481
MLA
Tang, C., Gao, C."Report and literature review on two cases with different kinds of Creutzfeldt-Jakob disease". Experimental and Therapeutic Medicine 15.1 (2018): 854-858.
Chicago
Tang, C., Gao, C."Report and literature review on two cases with different kinds of Creutzfeldt-Jakob disease". Experimental and Therapeutic Medicine 15, no. 1 (2018): 854-858. https://doi.org/10.3892/etm.2017.5481