Open Access

Different doses of folic acid and vitamin B12 to treat rabbits with deep venous thrombosis and hyperhomocysteinemia

  • Authors:
    • Xiao-Jun Shu
    • Zheng-Fei Li
    • Yao-Wen Chang
    • Sheng-Ye Liu
    • Wen-Hui Wang
    • Xiaoqiang Li
  • View Affiliations

  • Published online on: January 15, 2018     https://doi.org/10.3892/etm.2018.5751
  • Pages: 2874-2878
  • Copyright: © Shu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The effects of different doses of folic acid and vitamin B12 on rabbits with deep vein thrombosis (DVT) and hyperhomocysteinemia were investigated. In total, 60 New Zealand rabbits were divided into untreated control, low-dose and high-dose groups. After inducing DVT, hemorheology and coagulation indexes were measured 3 and 10 days later. We found that both treatment groups performed better than the control group, and the high-dose performed better than the low-dose. Ten days after thrombosis, the levels of Hcy and D-dimer were lower in the high-dose group. Moreover, the changes of lower extremity deep venous thrombosis were significantly reduced in both high- and low-dose groups, but the high-dose group showed the most improvement. The effective rate of the high-dose group was 100%, higher than the rate in the low-dose and control groups. Overall, high-dose of folic acid and vitamin B12 can significantly improve plasma Hcy, coagulation indexes, and pathological changes in the venous thrombosis of the lower extremity.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Shu X, Li Z, Chang Y, Liu S, Wang W and Li X: Different doses of folic acid and vitamin B12 to treat rabbits with deep venous thrombosis and hyperhomocysteinemia. Exp Ther Med 15: 2874-2878, 2018
APA
Shu, X., Li, Z., Chang, Y., Liu, S., Wang, W., & Li, X. (2018). Different doses of folic acid and vitamin B12 to treat rabbits with deep venous thrombosis and hyperhomocysteinemia. Experimental and Therapeutic Medicine, 15, 2874-2878. https://doi.org/10.3892/etm.2018.5751
MLA
Shu, X., Li, Z., Chang, Y., Liu, S., Wang, W., Li, X."Different doses of folic acid and vitamin B12 to treat rabbits with deep venous thrombosis and hyperhomocysteinemia". Experimental and Therapeutic Medicine 15.3 (2018): 2874-2878.
Chicago
Shu, X., Li, Z., Chang, Y., Liu, S., Wang, W., Li, X."Different doses of folic acid and vitamin B12 to treat rabbits with deep venous thrombosis and hyperhomocysteinemia". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2874-2878. https://doi.org/10.3892/etm.2018.5751