β-inducible gene-h3 promotes human breast carcinoma cell metastasis by activating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway

Zhang,Jiaxin; Li,Zhaojiangbo

doi:10.3892/etm.2018.5786

β-inducible gene-h3 promotes human breast carcinoma cell metastasis by activating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway

Authors:
- Jiaxin Zhang
- Zhaojiangbo Li
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Affiliations: Department of Breast Surgery, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of General Surgery Ward Two, Pingdu People's Hospital, Qingdao, Shandong 266700, P.R. China
Published online on: January 23, 2018 https://doi.org/10.3892/etm.2018.5786
Pages: 2910-2916
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metastatic breast cancer is one of the most common metastatic tumors. Although studies have validated the role of β-inducible gene-h3 (βig-h3) in human biology and disease, the detailed mechanisms mediated by βig‑h3 in breast carcinoma metastasis remain unclear. Thus, the present study investigated the role and potential mechanism of βig‑h3 during breast carcinoma cell metastasis. The results indicated that the upregulation of βig‑h3 significantly promotes the growth and inhibits the cisplatin‑induced apoptosis of breast carcinoma cells. It was also demonstrated that βig‑h3 promoted the migration and invasion of human breast carcinoma cells in vitro and in vivo. Furthermore, the results demonstrated that βig‑h3 upregulated the overall expression and phosphorylation of phosphatidylinositol 3‑kinase (PI3K) and protein kinase B (Akt) in human breast carcinoma cells. By contrast, βig‑h3 knockdown reversed the βig‑h3‑mediated characteristics of breast carcinoma cells. Thus, the current study demonstrated that the PI3K/Akt signaling pathway serves a role in βig‑h3‑induced human breast cancer cell metastasis and that βig‑h3 transfection enhances the metastatic potential of human breast carcinoma cells via the PI3K/Akt signaling pathway. These observations contribute to the understanding of the potential mechanism of human breast carcinoma cell growth and metastasis and suggest that βig‑h3 may be a promising therapeutic target for the treatment of human breast carcinoma.

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