Magnetic resonance imaging evaluation of characteristics of vascular invasion in intermediate and advanced hepatic alveolar echinococcosis

Yang,Xiaofei; Kang,Yingli; Qiao,Yijie; Li,Weixia; Cao,Jiayuan; Li,Hailong; Bao,Haihua

doi:10.3892/etm.2019.7460

Magnetic resonance imaging evaluation of characteristics of vascular invasion in intermediate and advanced hepatic alveolar echinococcosis

Authors:
- Xiaofei Yang
- Yingli Kang
- Yijie Qiao
- Weixia Li
- Jiayuan Cao
- Hailong Li
- Haihua Bao
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Affiliations: Imaging Center of Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, P.R. China, Department of Radiation Oncology, Medical College of Qinghai University, Xining, Qinghai 810001, P.R. China
Published online on: April 1, 2019 https://doi.org/10.3892/etm.2019.7460
Pages: 4197-4204

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Abstract

The objective of the present study was to provide a basis for the personalized treatment of intermediate and advanced hepatic alveolar echinococcosis (HAE) by elucidating the characteristics of vascular invasion and lesion growth. A total of 160 patients with intermediate and advanced HAE who were subjected to plain as well as contrast‑enhanced 3.0‑T magnetic resonance imaging prior to surgery were analyzed. Pathological and intra‑operative observations of the subjects were also considered. The size and location of HAE lesions, vascular invasion characteristics and growth patterns were assessed. A total of 78 patients (48.75%) had lesions involving the S5‑8 segment/partial right liver lobe, 21 (13.13%) had involvement in the S2‑4 segment/partial left liver lobe and 61 (38.13%) had lesions that transcended the left and right liver lobes. Pathological examination revealed that the vascular invasion rates of the hepatic portal veins, intrahepatic veins (left, central and right vein, and inferior vena cava) and hepatic arteries were 51.88, 43.28 and 26.87%, respectively. Liver hilum invasion was observed in 128 patients (80.00%), 71 of which (44.38%) presented with invasion of the primary porta hepatis, 11 (6.88%) with invasion of the secondary porta hepatis and 46 (28.75%) with invasion of the primary as well as the secondary porta hepatis. In conclusion, the growth pattern of intermediate and advanced HAE is determined by the site, blood supply and activity of the lesion. The current study demonstrated that lesions tend to invade the intrahepatic venous system and porta hepatis, and to target veins rather than arteries.

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1	Carmena D and Cardona GA: Echinococcosis in wild carnivorous species: Epidemiology, genotypic diversity, and implications for veterinary public health. Vet Parasitol. 202:69–94. 2014. View Article : Google Scholar : PubMed/NCBI
2	Farrokh D, Zandi B, Pezeshki Rad M and Tavakoli M: Hepatic alveolar echinococcosis. Arch Iran Med. 18:199–202. 2015.PubMed/NCBI
3	Ren L, Zhang LQ, Zhou FS, Fan HN, Deng Y, Wang HJ, Ma J, Wang Z and Luo SDW: Epidemiological investigation on hepatic hydatid disease in Banma county of Guoluo tibetan autonomous prefecture of Qinghai province. Chin J Dis Control Prev. 20:1032–1035. 2016.(In Chinese).
4	Mihmanli M, Idiz UO, Kaya C, Demir U, Bostanci O, Omeroglu S and Bozkurt E: Current status of diagnosis and treatment of hepatic echinococcosis. World J Hepatol. 28:1169–1181. 2016. View Article : Google Scholar
5	Jiang W, Wang J, Xiao H, Li TT, Liu H and Liu W: Evaluation of blood supply distribution of hepatic echinococcosis by dual-source CT energy imaging: correlation between iodine concentration and histopathology. J Xinjiang Med Univ. 38:1207–1212. 2015.(In Chinese).
6	Fang D, Chen ZY, Zeng Y, Li B, Wen TF, Wang WT, Wu H, Xu MQ, Yang JY, Wei YG, et al: Surgical treatment of hepatic alveolar echinococcosis. Chin J Bases Clin in General Surg. 23:521–525. 2016.(In Chinese).
7	Chen KF, Tang YY, Wang R, Fang D, Chen JH, Zeng Y, Li B, Wen TF, Wang WT, Wu H, et al: The choose of different surgical therapies of hepatic alveolar echinococcosis: A single-center retrospective case-control study. Medicine (Baltimore). 97:e00332018. View Article : Google Scholar : PubMed/NCBI
8	Zhang SJ, Zhang L, Zhao JQ, Zhang YG, Wu XW, Peng XY, Cao YW, Yang HQ, Lv HL, Sun H and Chen XP: Inhibition of invasive growth and metastasis of hepatic alveolar echinococcosis by anti-osteopontin antibody. Chin J Parasitol Parasit Dis. 29:410–414. 2011.(In Chinese).
9	He YB, Bai L, Aji T, Jiang Y, Zhao JM, Zhang JH, Shao YM, Liu WY and Wen H: Application of 3D reconstruction for surgical treatment of hepatic alveolar echinococcosis. World J Gastroenterol. 35:10200–10207. 2015. View Article : Google Scholar
10	Li HL, Hou LC, Ren L, Fan HN, Bao HH, Wen SB and Li WX: Significance of magnetic resonance imaging in preoperative evaluation for patients with hepatic alveolar echinococcosis. Chin J Bases Clin in General Surg. 23:535–538. 2016.(In Chinese).
11	Sanaat Z, Khalili R, Almasi S, Aliparasti MR, Tavangar SM, Movasaghpoor A, Kazemi F and Davani A: Does chemotherapy change expression of VEGF A&C and MVD in acute myeloid leukemia? Int J Hematol Oncol Stem Cell Res. 8:24–29. 2014.PubMed/NCBI
12	Ramnefjell M, Aamelfot C, Helgeland L and Akslen LA: Vascular invasion is an adverse prognostic factor in resected non-small-cell lung cancer. APMIS. 125:197–206. 2017. View Article : Google Scholar : PubMed/NCBI
13	Geramizadeh B, Attaran Y, Malek-Hosseini SA, Kaviani MJ and Hossieni-Asl K: Photoclinic. Alveolar hydatid cyst of the liver. Arch Iran Med. 14:211–212. 2011.PubMed/NCBI
14	Piarroux M, Piarroux R, Giorgi R, Knapp J, Bardonnet K, Sudre B, Watelet J, Dumortier J, Gérard A, Beytout J, et al: Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: Results of a survey in 387 patients. J Hepatol. 55:1025–1033. 2011. View Article : Google Scholar : PubMed/NCBI
15	Vuitton DA and Bresson-Hadni S: Alveolar echinococcosis: Evaluation of therapeutic strategies. J Expert Opin Orphan Drugs. 2:67–86. 2014. View Article : Google Scholar
16	Nunnari G, Pinzone MR, Gruttadauria S, Celesia BM, Madeddu G, Malaguarnera G, Pavone P, Cappellani A and Cacopardo B: Hepatic echinococcosis: Clinical and therapeutic aspects. World J Gastroenterol. 18:1448–1458. 2012. View Article : Google Scholar : PubMed/NCBI
17	Wen H, Dong JH, Zhang JH, Zhao JM, Shao YM, Liang YR and Ji XW: Ex-vivo liver resection combined liver autotransplantation for the treatment of hepatic alveolar echinococcosis. Chin J Dig Surg. 10:148–149. 2011.
18	Qian NS, Liao YH, Cai SW, Rautd V and Dong JH: Comprehensive application of modern technologies in precise liver resection. Hepatobiliary Pancreat Dis Int. 12:244–250. 2013. View Article : Google Scholar : PubMed/NCBI
19	Thian YL, Riddell AM and Koh DM: Liver-specific agents for contrast-enhanced MRI: Role in oncological imaging. Cancer Imaging. 13:567–579. 2013. View Article : Google Scholar : PubMed/NCBI
20	Sun YQ, Zhang YH, Yang M, Wang JJ and Zhang QX: Application of CT and MRI in Ex-vivo autologous liver transplantation of advanced hepatic alveolar echinococcosis. Chin J Med Imaging. 23:610–613. 2015.(In Chinese).
21	Wang J, Huang Y, Zhao YP, Liu WY, Wang J and Liu XL: Preoperative multi-slice spiral CT evaluation of involvement of vessels and biliary ducts in hepatic cystic echinococcosis. Chin J Radiol. 44:397–400. 2010.
22	Wu JW, Qu XL, Gao H, Lv MG, Lu L and Wang Xuan: Application of LAVA CE-MRA in hepatectomy for huge hepatic tumor. Chin J Prac Surg. 33:960–963. 2013.
23	Goceri E: Automatic labeling of portal and hepatic veins from MR images prior to liver transplantation. Int J Comput Assist Radiol Surg. 11:2153–2161. 2016. View Article : Google Scholar : PubMed/NCBI
24	Li Q, Lai SL, Zhang W, Jin GQ, Wang C, Su DK and Xie D: Radiologic hepatic capsular invasion on msct in prediction of microvascular invasion of hepatocellular carcinoma. J Clin Radiol. 6:838–840. 2017.
25	Conraths FJ, Probst C, Possenti A, Boufana B, Saulle R, La Torre G, Busani L and Casulli A: Potential risk factors associated with human alveolar echinococcosis: Systematic review and meta-analysis. PLoS Negl Trop Dis. 11:e00058012017. View Article : Google Scholar : PubMed/NCBI
26	Baheti AD, Dunham GM, Ingraham CR, Moshiri M, Lall C, Park JO, Li D, Katz DS, Madoff DC and Bhargava P: Clinical implications for imaging of vascular invasion in hepatocellular carcinoma. Abdom Radiol (NY). 41:1800–1810. 2016. View Article : Google Scholar : PubMed/NCBI
27	Fan YX, Ren WX, Bawudun D, Ji WZ, Gu JP, Xu XD and Zhang HX: Digital subtraction angiographic observation on blood supply of rat's hepatic alveolar echinococcosis. Chin J Interv Imaging Ther. 9:37–40. 2012.
28	Ren WX and Xiao XS: The blood supply of portal vein in experimentalhepatic alveolar echinococcosis. Chin J Interv Imaging Ther. 4:142–147. 2007.