Relationship between XRCC1 and XPD polymorphisms and the risk of the development of hepatocellular carcinoma: A case-control study

Yuan,Tao; Deng,Shaoli; Liu,Hongming; Liu,Menggang; Chen,Ping

doi:10.3892/etm.2012.581

Relationship between XRCC1 and XPD polymorphisms and the risk of the development of hepatocellular carcinoma: A case-control study

Authors:
- Tao Yuan
- Shaoli Deng
- Hongming Liu
- Menggang Liu
- Ping Chen
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Affiliations: Department of Hepatobiliary Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China, Department of Clinical Laboratory Medicine, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China
Published online on: May 17, 2012 https://doi.org/10.3892/etm.2012.581
Pages: 285-290

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Abstract

Hepatocellular carcinoma (HCC) is a serious public health issue, the incidence of which is considered to be closely related to tobacco smoking, alcohol consumption, hepatitis B virus (HBV) infection and family history. The DNA repair system is an important protective mechanism against the development of malignant cells induced by internal and external environmental factors. The aim of this study was to investigate the association of polymorphisms of XRCC1-194, XRCC1-280 and XPD-312 DNA repair genes and the risk of development of HCC in Han Chinese patients. A case‑control design was used including 252 HCC inpatients and 250 healthy controls recruited and matched by age, gender, tobacco smoking, alcohol consumption, HBV infection and family history. XPD Asp312Asn, XRCC1 Arg194Trp and XRCC1 Arg280His genes were examined using a sequencing assay method. Distributions of the genotype frequency and odds ratio (OR) between the two groups were analyzed. The results demonstrated that there was no significant difference in the frequencies of XPD Asp312Asn, XRCC1 Arg194Trp and XRCC1 Arg280His in the HCC cases and the control group. In the stratified analysis of different allele genotypes, the frequency of the XRCC1-194 site genotype was not significantly different between the case and control group. The presence of the XRCC1 280His genotype was associated with a significantly increased risk of HCC under conditions of HBV infection and family history [OR (95% CI): 1.68 (1.08-2.60), 4.20 (1.34-13.20), respectively]. Similarly, the XPD 312Asn significantly increased the risk of HCC under conditions of alcohol consumption, tobacco smoking, HBV infection and family history [OR (95% CI): 1.67 (1.10-2.60), 1.87 (1.18-2.96), 1.96 (1.24-3.10), 3.40 (1.32-8.76), respectively]. In conclusion, tobacco smoking and alcohol consumption are high risk factors of HCC for the XPD 312Asn genotype; HBV infection and family history increase the risk of HCC for the genotypes XRCC1 280His and XPD 312Asn.

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1.	Silvestri L, Sonzogni L, De Silvestri A, et al: CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer. Int J Cancer. 104:310–317. 2003. View Article : Google Scholar : PubMed/NCBI
2.	Kirk GD, Lesi OA, Mendy M, et al: 249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepato-cellular carcinoma. Oncogene. 24:5858–5867. 2005. View Article : Google Scholar : PubMed/NCBI
3.	Hara A, Sakata K, Yamada Y, et al: Suppression of β-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats. Oncol Rep. 14:345–351. 2005.
4.	Marrero JA, Fontana RJ, Fu S, et al: Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma. J Hepatol. 42:218–224. 2005. View Article : Google Scholar : PubMed/NCBI
5.	Zhang X, Miao X, Liang G, et al: Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. Cancer Res. 65:722–726. 2005.PubMed/NCBI
6.	Gerlitz G: HMGNs. DNA repair and cancer. Biochim Biophys Acta. 1799:80–85. 2010. View Article : Google Scholar : PubMed/NCBI
7.	Song DK, Xing DL, Zhang LR, et al: Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China. Cancer Detect Prev. 32:416–423. 2009. View Article : Google Scholar : PubMed/NCBI
8.	Ginsberg G, Angle K, Guyton K and Sonawane B: Polymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment. Mutat Res. 727:13–15. 2011. View Article : Google Scholar : PubMed/NCBI
9.	Lindahl T and Wood RD: Quality control by DNA repair. Science. 286:1897–1905. 1999. View Article : Google Scholar : PubMed/NCBI
10.	Shen MR, Jones LM and Mohrenweiser H: Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res. 58:604–608. 1998.PubMed/NCBI
11.	Xing D, Qi J, Miao X, et al: Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population. Int J Cancer. 100:600–605. 2002. View Article : Google Scholar : PubMed/NCBI
12.	Lee SG, Kim B, Choi J, et al: Genetic polymorphisms of XRCC1 and risk of gastric cancer. Cancer Lett. 187:53–60. 2002. View Article : Google Scholar : PubMed/NCBI
13.	Park JY, Lee SY, Jeon HS, et al: Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev. 11:23–27. 2002.
14.	Kim SU, Park SK, Yoo KY, et al: XRCC1 genetic polymorphism and breast cancer risk. Pharmacogenetics. 12:335–338. 2002. View Article : Google Scholar : PubMed/NCBI
15.	Au WW, Salama SA and Sierra-Torres CH: Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays. Environ Health Perspect. 111:1843–1850. 2003. View Article : Google Scholar : PubMed/NCBI
16.	Liang G, Xing D, Miao XD, et al: Sequence variations in the DNA repair gene XPD and risk of lung cancer in a Chinese population. Int J Cancer. 105:669–673. 2003. View Article : Google Scholar : PubMed/NCBI
17.	Abdel-Rahman SZ, Soliman AS, Bondy ML, et al: Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt. Cancer Lett. 159:79–86. 2000. View Article : Google Scholar : PubMed/NCBI
18.	David-Beabes GL and London SJ: Genetic polymorphism of XRCC1 and lung cancer risk among African-Americans and Caucasians. Lung Cancer. 34:333–339. 2001. View Article : Google Scholar : PubMed/NCBI
19.	Lunn RM, Langlois RG, Hsieh LL, et al: XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res. 59:2557–2561. 1999.PubMed/NCBI
20.	Kiran M, Saxena R, Chawla YK, et al: Polymorphism of DNA repair gene XRCC1 and hepatitis-related hepatocellular carcinoma risk in Indian population. Mol Cell Biochem. 327:7–13. 2009. View Article : Google Scholar : PubMed/NCBI
21.	Cheng L, Spitz MR, Hong WK and Wei Q: Reduced expression levels of nucleotide excision repair genes in lung cancer. Carcinogenesis. 21:1527–1530. 2000. View Article : Google Scholar : PubMed/NCBI
22.	Vogel U, Nexø BA, Tjønneland A, et al: ERCC1, XPD and RAI mRNA levels in lymphocytes are not associated with lung cancer risk in a prospective study of Danes. Mutat Res. 593:88–96. 2006. View Article : Google Scholar : PubMed/NCBI
23.	Long XD, Ma Y, Zhou YF, et al: XPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk. BMC Cancer. 17:4002009. View Article : Google Scholar : PubMed/NCBI
24.	Long XD, Ma Y, Wei YP, et al: The polymorphisms of GSTM1, GSTT1, HYL1^*2, and XRCC1, and aflatoxin B1-related hepatocellular carcinoma in Guangxi population, China. Hepatol Res. 36:48–55. 2006.PubMed/NCBI