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DNA mismatch repair genes and their association with colorectal cancer (Review).

  • Authors:
    • A Whitehouse
    • D M Meredith
    • A F Markham

  • View Affiliations

  • Published online on: February 1, 1998     https://doi.org/10.3892/ijmm.1.2.469
  • Pages: 469-543
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Abstract

Mismatch repair genes are involved in increasing the fidelity of replication by specific repair of DNA polymerase incorporation errors. In Escherichia coli, the best studied mismatch repair (MMR) pathway is the methyl-directed long patch repair system which is mediated by three gene products; MutS, MutL and MutH. These are conserved in higher eukaryotes. Mutations in human homologues of these proteins have been shown to be implicated in hereditary non-polyposis colorectal cancer (HNPCC). Alterations in the coding regions of MMR genes result in a mutator phenotype with marked instability of microsatellite sequences, indicative of a deficiency in DNA repair.

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Feb 1998
Volume 1 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Whitehouse A, Meredith D and Markham A: DNA mismatch repair genes and their association with colorectal cancer (Review).. Int J Mol Med 1: 469-543, 1998
APA
Whitehouse, A., Meredith, D., & Markham, A. (1998). DNA mismatch repair genes and their association with colorectal cancer (Review).. International Journal of Molecular Medicine, 1, 469-543. https://doi.org/10.3892/ijmm.1.2.469
MLA
Whitehouse, A., Meredith, D., Markham, A."DNA mismatch repair genes and their association with colorectal cancer (Review).". International Journal of Molecular Medicine 1.2 (1998): 469-543.
Chicago
Whitehouse, A., Meredith, D., Markham, A."DNA mismatch repair genes and their association with colorectal cancer (Review).". International Journal of Molecular Medicine 1, no. 2 (1998): 469-543. https://doi.org/10.3892/ijmm.1.2.469