Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).

  • Authors:
    • M López-Hoyos
    • R Carrió
    • J Merino
    • R Merino
  • View Affiliations

  • Published online on: February 1, 1998     https://doi.org/10.3892/ijmm.1.2.475
  • Pages: 475-558
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Abstract

Cell death is a common event during B cell development. The demise of developing B cells is a regulated process that serves to select cell populations bearing functional receptors and to remove cells that are no longer needed or potentially autoreactive. Bcl-2 and Bcl-XL, two members of the bcl-2 gene family of programmed cell death regulators with anti-apoptotic activity, are expressed in a highly regulated pattern during B cell maturation. Overexpression of Bcl-2 in developing B cells of transgenic mice, in the presence of T cell dependent costimulatory signals, results in the generation of a modified B cell repertoire and in the production of pathogenic autoantibodies. While disregulation of programmed cell death in B cells may cause autoimmune manifestations in mice, the involvement of such alterations in the pathogenesis of autoimmune diseases in humans merits further investigation.

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Feb 1998
Volume 1 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
López-Hoyos M, Carrió R, Merino J and Merino R: Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).. Int J Mol Med 1: 475-558, 1998.
APA
López-Hoyos, M., Carrió, R., Merino, J., & Merino, R. (1998). Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).. International Journal of Molecular Medicine, 1, 475-558. https://doi.org/10.3892/ijmm.1.2.475
MLA
López-Hoyos, M., Carrió, R., Merino, J., Merino, R."Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).". International Journal of Molecular Medicine 1.2 (1998): 475-558.
Chicago
López-Hoyos, M., Carrió, R., Merino, J., Merino, R."Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).". International Journal of Molecular Medicine 1, no. 2 (1998): 475-558. https://doi.org/10.3892/ijmm.1.2.475