Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review).

  • Authors:
    • T Murata
    • N I Obiri
    • R K Puri
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijmm.1.3.551
  • Pages: 551-558
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Abstract

We have recently demonstrated that two different forms of IL-4R exist; classical or alternative. The classical IL-4R is predominantly expressed in hematopoietic cells and consist of IL-4R and IL-2Rgammac (gammac) chains. On the other hand, alternative form of IL-4R is predominantly expressed in non-hematopoietic cells and consists of IL-4R and IL-13Ralpha' chains. Moreover, the alternative form of IL-4R is also utilized as a functional component IL-13R complex. It has been shown that the phosphorylation and activation of JAK3 tyrosine kinase is crucial for IL-4 activation of STAT6 in hematopoietic cells. However, we have recently demonstrated that non-hematopoietic cells lack JAK3 expression. We also demonstrated that in these cells, STAT6 activation is mediated through JAK1 and JAK2 tyrosine kinases instead. Furthermore, our results show that IL-4 and IL-13 signals are transmitted through the alternative form of IL-4R in these cells. Thus, major differences exist between hematopoietic and non-hematopoietic cells with regard to structure and signal transduction through IL-4R and IL-13R systems.

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Mar 1998
Volume 1 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Murata T, Obiri N and Puri R: Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review).. Int J Mol Med 1: 551-558, 1998.
APA
Murata, T., Obiri, N., & Puri, R. (1998). Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review).. International Journal of Molecular Medicine, 1, 551-558. https://doi.org/10.3892/ijmm.1.3.551
MLA
Murata, T., Obiri, N., Puri, R."Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review).". International Journal of Molecular Medicine 1.3 (1998): 551-558.
Chicago
Murata, T., Obiri, N., Puri, R."Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review).". International Journal of Molecular Medicine 1, no. 3 (1998): 551-558. https://doi.org/10.3892/ijmm.1.3.551