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Increased serum levels of tumor necrosis factor-alpha are correlated to soluble intercellular adhesion molecule-1 concentrations in non-small cell lung cancer patients.

  • Authors:
    • F De Vita
    • M Orditura
    • S Infusino
    • A Auriemma
    • G Catalano

  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijmm.1.3.605
  • Pages: 605-613
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Abstract

Tumor necrosis factor (TNF)-alpha has been shown to induce shedding of ICAM-1. Experimental studies report that soluble intercellular adhesion molecule-1 (sICAM-1) may interfere with the host immunesurveillance system. Serum levels of TNF-alpha and sICAM-1 were determined by ELISA in 112 non-small cell lung cancer (NSCLC) patients. Serum concentration of TNF-alpha and sICAM-1 were related to tumor burden and progression; a significant correlation was observed between circulating levels of TNF-alpha and sICAM-1. Our study suggests that ICAM-1 could be a marker of TNF-alpha activity and that high levels of these molecules may have a prognostic value in lung cancer.

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Mar 1998
Volume 1 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
De Vita F, Orditura M, Infusino S, Auriemma A and Catalano G: Increased serum levels of tumor necrosis factor-alpha are correlated to soluble intercellular adhesion molecule-1 concentrations in non-small cell lung cancer patients.. Int J Mol Med 1: 605-613, 1998
APA
De Vita, F., Orditura, M., Infusino, S., Auriemma, A., & Catalano, G. (1998). Increased serum levels of tumor necrosis factor-alpha are correlated to soluble intercellular adhesion molecule-1 concentrations in non-small cell lung cancer patients.. International Journal of Molecular Medicine, 1, 605-613. https://doi.org/10.3892/ijmm.1.3.605
MLA
De Vita, F., Orditura, M., Infusino, S., Auriemma, A., Catalano, G."Increased serum levels of tumor necrosis factor-alpha are correlated to soluble intercellular adhesion molecule-1 concentrations in non-small cell lung cancer patients.". International Journal of Molecular Medicine 1.3 (1998): 605-613.
Chicago
De Vita, F., Orditura, M., Infusino, S., Auriemma, A., Catalano, G."Increased serum levels of tumor necrosis factor-alpha are correlated to soluble intercellular adhesion molecule-1 concentrations in non-small cell lung cancer patients.". International Journal of Molecular Medicine 1, no. 3 (1998): 605-613. https://doi.org/10.3892/ijmm.1.3.605